目的 探討桂蒲腎清膠囊聯(lián)合磷霉素氨丁三醇顆粒治療下尿路感染的臨床療效。方法 選擇2018年7月—2020年7月在天津市北辰醫(yī)院治療的108例下尿路感染患者，根據(jù)使用藥物的差別分成對(duì)照組和治療組，每組各54例。對(duì)照組口服磷霉素氨丁三醇顆粒，3 g/次，1次/d。治療組在對(duì)照組基礎(chǔ)上口服桂蒲腎清膠囊，4粒/次，3次/d。兩組患者均治療5 d。觀察兩組患者臨床療效，比較治療前后兩組患者尿細(xì)菌培養(yǎng)轉(zhuǎn)陰率和癥狀消失時(shí)間，及血清超敏C反應(yīng)蛋白（hs-CRP）、白細(xì)胞介素-6（IL-6）、單核細(xì)胞趨化蛋白-1（MCP-1）、血紅素氧合酶1（HO-1）和降鈣素原（PCT）水平。結(jié)果 治療后，治療組總有效率為96.30%，明顯高于對(duì)照組的83.33%（P<0.05）。治療后，治療組患者尿細(xì)菌培養(yǎng)轉(zhuǎn)陰率為98.15%，顯著高于對(duì)照組的81.48%（P<0.05）。與對(duì)照組相比，治療組排尿灼急、腰酸痛、小便澀痛、小腹墜脹癥狀消失時(shí)間明顯縮短（P<0.05）。治療后，兩組患者血清hs-CRP、IL-6、MCP-1、HO-1、PCT水平均顯著降低（P<0.05），且治療組降低更顯著（P<0.05）。結(jié)論 桂蒲腎清膠囊聯(lián)合磷霉素氨丁三醇顆粒治療下尿路感染效果顯著，同時(shí)在改善患者臨床不適癥狀和炎癥因子水平方面也有著積極意義。

Objective To investigate the efficacy of Guipu Shenqing Capsules combined with fosfomycin tromethamine in treatment of lower urinary tract infection. Methods Patients (108 cases) with lower urinary tract infection in Tianjin Beichen Hospital from July 2018 to July 2020 were divided into control and treatment groups according to the difference drugs, and each group had 54 cases. Patients in the control group were po administered with Fosfomycin Trometamol Granules, 3 g/time, once daily. Patients in the treatment group po administered with Guipu Shenqing Capsules on the basis of the control group, 4 capsules /time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the negative conversion rate of urine bacterial culture, the symptom disappearance time, and the serum levels of hs-CRP, IL-6, MCP-1, HO-1, and PCT in two groups before and after treatment were compared.Results After treatment, the clinical effective rate of the treatment group was 96.30%, which was significantly higher than 83.33% of the control group (P<0.05). After treatment, the negative conversion rate of urinary bacterial culture in the treatment group was 98.15%, which was significantly higher than 81.48% in the control group (P<0.05). Compared with the control group, the disappearance time of urgent urination, low back pain, astringent urination, and abdominal distension in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the serum levels of hs-CRP, IL-6, MCP-1, HO-1, and PCT in two groups were significantly decreased (P<0.05), especially in the treatment group (P<0.05). Conclusion The effect of Guipu Shenqing Capsule combined with fosfomycin tromethamine in treatment of lower urinary tract infection is significant, and which also has positive significance in improving patients' clinical discomfort symptoms and the level of inflammatory factors.

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