目的 探討雞膽口服液聯(lián)合頭孢克肟治療急性上呼吸道感染的臨床療效。方法 選取2018年3月—2019年3月在天津市濱海新區(qū)大港醫(yī)院治療的106例急性上呼吸道感染患者，根據(jù)隨機(jī)數(shù)字表法分為對(duì)照組（53例）和治療組（53例）。對(duì)照組患者口服頭孢克肟片，100 mg/次，2次/d；治療組在對(duì)照組的基礎(chǔ)上口服雞膽口服液，20 mL/次，3次/d，兩組患者均連續(xù)治療7 d。觀察兩組患者臨床療效，比較治療前后兩組患者臨床癥狀消退時(shí)間，血清白細(xì)胞介素6（IL-6）、IL-8、C反應(yīng)蛋白（CRP）和腫瘤壞死因子α（TNF-α）水平及不良反應(yīng)情況。結(jié)果 治療后，治療組患者臨床總有效率為98.11%，顯著高于對(duì)照組的79.25%（P<0.05）；治療后，治療組患者的發(fā)熱消退時(shí)間、咽部紅腫消退時(shí)間、咳嗽消退時(shí)間均短于對(duì)照組患者（P<0.05）；治療后，兩組患者IL-6、IL-8、CRP、TNF-α水平均顯著低于治療前（P<0.05），且治療組患者明顯低于對(duì)照組（P<0.05）；治療組不良反應(yīng)發(fā)生率為7.55%，顯著低于對(duì)照組的24.53%。結(jié)論 雞膽口服液聯(lián)合頭孢克肟治療急性上呼吸道感染，能有效縮短臨床癥狀消失時(shí)間和改善機(jī)體免疫功能水平，明顯改善炎性因子水平。

Objective To investigate the curative effect of Jidan Oral Liquid combined with cefixime in treatment of acute upper respiratory tract infection. Methods Patients (106 cases) with acute upper respiratory tract infection in Dagang Hospital of Tianjin Binhai New District from March 2018 to March 2019 were randomly divided into control (53 cases) and treatment (53 cases) groups. Patients in the control group were po administered with Cefixime Tablets, 100 mg/time, twice daily. Patients in the treatment group were po administered with Jidan Oral Liquid on the basis of the control group, 20 mL/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, and the serum levels of IL-6, IL-8, CRP, and TNF-α, and adverse reaction in two groups before and after treatment were compared. Results After treatment, the total clinical effective rate of the treatment group was 98.11%, which was significantly higher than 79.25% of the control group (P<0.05). After treatment, the disappearance time of fever, pharynx, and cough in the treatment group was shorter than that in the control group (P<0.05). After treatment, the levels of IL-6, IL-8, CRP, and TNF- α in both groups were significantly lower than those before treatment (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). The total incidence of adverse reactions in the treatment group was 7.55%, which was significantly lower than 24.53% in the control group (P<0.05).Conclusion Jidan Oral Liquid combined with cefixime in treatment of acute upper respiratory tract infection can effectively shorten the disappearance time of clinical symptoms and improve the level of immune function, and significantly improve the level of inflammatory factors.

R974