目的 探討炎熱清顆粒聯(lián)合阿奇霉素治療小兒毛細(xì)支氣管炎的臨床療效。方法 選取2019年12月—2020年12月周口永善醫(yī)院收治的100例小兒毛細(xì)支氣管炎患兒，采用隨機(jī)數(shù)表法將患兒分成對(duì)照組和治療組，每組50例。對(duì)照組口服阿奇霉素顆粒，體質(zhì)量≤15 kg，0.1 g/次，1次/d；15 kg<體質(zhì)量≤25 kg，0.2 g/次，1次/d。治療組在對(duì)照組的治療基礎(chǔ)上口服炎熱清顆粒，3 g/次，3次/d。兩組患兒連續(xù)治療5 d。觀察兩組的臨床療效和臨床癥狀消失時(shí)間，比較兩組炎癥因子指標(biāo)在治療前后的變化情況。結(jié)果 治療組總有效率為96.0%，顯著高于對(duì)照組的84.0%（P<0.05）。治療后，治療組退熱時(shí)間、干濕性啰音消失時(shí)間、喘憋消失時(shí)間、咳嗽痰響消失時(shí)間和住院時(shí)間明顯短于對(duì)照組（P<0.05）。治療后，兩組患兒干擾素-γ（INF-γ）水平顯著高于治療前水平，但腫瘤壞死因子α（TNF-α）、白細(xì)胞介素-10（IL-10）、白細(xì)胞介素-2（IL-2）平明顯低于治療前（P<0.05）；治療后，治療組血清炎癥因子水平改善優(yōu)于對(duì)照組（P<0.05）。結(jié)論 炎熱清顆粒聯(lián)合阿奇霉素治療小兒毛細(xì)支氣管炎效果顯著，可有效緩解患兒的臨床癥狀，降低炎癥因子，具有一定的臨床應(yīng)用價(jià)值。

Objective To investigate the curative effect of Yanreqing Granules combined with azithromycin in treatment of pediatric bronchiolitis. Methods A total of 100 children with bronchiolitis admitted to Zhoukou Yongshan Hospital from December 2019 to December 2020 were selected. The children were divided into control group and treatment group by random number table method, with 50 cases in each group. Patients in the control group were po administered with Azithromycin Granules, body weight ≤15 kg, 0.1 g/time, once daily, 15 kg po administered with Yanreqing Granules on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 5 d. After treatment, clinical efficacy and disappearance time of clinical symptoms was evaluated, and the changes of inflammatory cytokines before and after treatment were compared between the two groups. Results The total effective rate of the treatment group was 96.0%, which was significantly higher than that of the control group (84.0%, P<0.05). After treatment, the fever abatement time, dry and wet rale disappeared time, wheezing disappeared time, cough, and phlegm disappeared time and hospitalization time in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the level of interferon-γ (INF-γ) in two groups was significantly higher than that before treatment, but tumor necrosis factor α (TNF-α), interleukin-10 (IL-10), and interleukin-2 (IL-2) were significantly lower than that before treatment (P<0.05). After treatment, the improvement of serum inflammatory cytokines in treatment group was better than that in control group (P<0.05). Conclusion Yanreqing Granules combined with azithromycin has significant effect in treatment of pediatric bronchiolitis, and can effectively alleviate the clinical symptoms of children, reduce inflammatory factors, which has a certain value of clinical application.

R985

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃項(xiàng)目（LHGJ20190971）