目的 探討杜仲顆粒聯(lián)合拉貝洛爾治療妊娠期高血壓的臨床療效。方法 選取2018年6月—2020年6月在鄭州大學(xué)附屬南陽市中心醫(yī)院進(jìn)行治療的126例妊娠期高血壓患者，根據(jù)用藥差別分為對(duì)照組（63例）和治療組（63例）。對(duì)照組口服鹽酸拉貝洛爾片，0.1 g/次，2次/d，服用3 d后根據(jù)需要加量，維持劑量為0.2～0.4 g，2次/d，每日最大量2.4 g；治療組在對(duì)照組基礎(chǔ)上口服杜仲顆粒，5 g/次，2次/d。兩組治療7 d對(duì)比臨床效果。觀察兩組的臨床療效，比較兩組治療前后血壓、血清學(xué)指標(biāo)的變化情況。結(jié)果 經(jīng)治療，治療組總有效率是98.41%，顯著高于對(duì)照組的82.54%（P<0.05）。經(jīng)治療，兩組收縮壓（SBP）、舒張壓（DBP）均較治療前顯著下降（P<0.05）；且治療后，治療組SBP、DBP低于對(duì)照組（P<0.05)。經(jīng)治療，兩組血清妊娠關(guān)聯(lián)血漿蛋白A（PAPPA）、同型半胱氨酸（Hcy）、γ干擾素誘導(dǎo)蛋白16（IFI16）水平均顯著下降，而胎盤生長(zhǎng)因子（PLGF）、轉(zhuǎn)甲狀腺素蛋白（TTR）、人可溶性血管內(nèi)皮生長(zhǎng)因子1（sFIt-1）水平均顯著增高（P<0.05)；治療后，治療組血清學(xué)指標(biāo)改善優(yōu)于對(duì)照組（P<0.05）。結(jié)論 杜仲顆粒聯(lián)合拉貝洛爾治療妊娠期高血壓效果顯著，可有效改善機(jī)體血清PAPPA、Hcy、IFI16、PLGF、TTR、sFIt-1水平，有著良好的臨床應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Duzhong Granules combined with labetalol in treatment of gestational hypertension.Methods A total of 126 patients with gestational hypertension who were treated in Nanyang Central Hospital Affiliated to Zhengzhou University from June 2018 to June 2020 were selected and divided into control group (63 cases) and treatment group (63 cases) according to medication difference. Patients in the control group were po administered with Labetalol Hydrochloride Tablets, 0.1 g/time, twice daily. After 3 days, the dosage was increased as needed. The maintenance dosage was 0.2 — 0.4 g, twice daily, and the maximum amount was 2.4 g/d. Patients in the treatment group were po administered with Duzhong Granules on the basis of the control group, 5 g /time, twice daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the levels of blood pressure and serological indexes before and after treatment were compared between the two groups.Results After treatment, the total effective rate of the treatment group was 98.41%, which was significantly higher than that of the control group (82.54%,P<0.05). After treatment, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in two groups were significantly decreased compared with before treatment (P<0.05). After treatment, SBP and DBP in treatment group were lower than those in control group (P<0.05). After treatment, the serum levels of PAPPA, Hcy and IFI16 decreased significantly in both groups, but the levels of PLGF, TTR and SFT-1 were significantly increased (P<0.05). After treatment, the improvement of serological indexes in the treatment group was better than that in the control group (P<0.05).Conclusion Duzhong Granules combined with labetalol has a significant effect in treatment of gestational hypertension, and can effectively improve serum levels of PAPPA, Hcy, IFI16, PLGF, TTR, and sFIt-1, which has a good clinical application value.

R984

河南省科技攻關(guān)項(xiàng)目（201702564）