目的 探討益膽片聯(lián)合左氧氟沙星治療急性膽囊炎的臨床療效。方法 選擇2020年2月—2020年9月在平煤神馬醫(yī)療集團(tuán)總醫(yī)院治療的106例急性膽囊炎患者，根據(jù)住院順序分成對照組（53例）和治療組（53例）。對照組靜脈滴注鹽酸左氧氟沙星注射液，0.2 g加入生理鹽水250 mL，2次/d。治療組在對照組基礎(chǔ)上口服益膽片，3片/次，3次/d。兩組患者均治療1周。觀察兩組患者臨床療效，比較治療前后兩組患者臨床癥狀改善時間及血清學(xué)指標(biāo)超敏C反應(yīng)蛋白（hs-CRP）、巨噬細(xì)胞集落刺激因子（M-CSF）、巨噬細(xì)胞移動抑制因子（MIF）、降鈣素原（PCT）和抵抗素水平。結(jié)果 經(jīng)治療，對照組總有效率為84.91%，顯著低于治療組的98.11%（P<0.05）。經(jīng)治療，治療組在腹痛緩解時間、腹脹緩解時間、退熱時間、惡心嘔吐緩解時間上均優(yōu)于對照組（P<0.05）。經(jīng)治療，兩組患者血清hs-CRP、M-CSF、MIF、PCT、抵抗素水平均顯著降低（P<0.05），治療組最顯著（P<0.05）。結(jié)論 益膽片聯(lián)合左氧氟沙星治療急性膽囊炎可有效改善患者臨床癥狀，降低機(jī)體炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Yidan Tablets combined with levofloxacin in treatment of acute cholecystitis. Methods Patients (106 cases) with acute cholecystitis in General Hospital of Pingmei Shenma Medical Group from February 2020 to September 2020 were randomly divided into control (53 cases) and treatment (53 cases) groups based on hospitalization order. Patients in the control group were iv administered with Levofloxacin Hydrochloride Injection, 0.2 g added into normal saline 250 mL, twice daily. Patients in the treatment group were po administered with Yidan Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the improvement time of clinical symptoms, and the levels of serological indexes hs-CRP, M-CSF, MIF, PCT, and resistin in two groups before and after treatment were compared. Results After treatment, the effective rate of the control group was 84.91%, which was significantly lower than 98.11% of the treatment group (P<0.05). After treatment, abdominal pain relief time, abdominal distension relief time, antipyretic time, nausea and vomiting relief time in treatment group was shorter than that of the control group (P<0.05). After treatment, the levels of serum hs-CRP, M-CSF, MIF, PCT, and resistin in two groups were significantly decreased (P<0.05), especially in the treatment group (P<0.05). Conclusion Yidan Tablets combined with levofloxacin in treatment of acute cholecystitis can effectively improve the clinical symptoms, and reduce the body inflammatory reaction, which has a certain clinical application value.

R975