目的 探討丁細牙痛膠囊聯(lián)合鹽酸米諾環(huán)素軟膏治療慢性牙髓炎的臨床療效。方法 選取2019年6月—2021年1月天津市口腔醫(yī)院收治的94例慢性牙髓炎患者，按照隨機數(shù)字表法將所有患者分為對照組和治療組，每組各47例。對照組患者將患齒根管內(nèi)涂抹鹽酸米諾環(huán)素軟膏，根管封藥，1次/d。治療組在對照組基礎(chǔ)上口服丁細牙痛膠囊，4粒/次，3次/d。兩組患者連續(xù)治療4周?？疾旎颊叩目傆行?，并比較兩組患者治療后的疼痛程度和血清炎性因子水平。結(jié)果 治療后，治療組患者的總有效率為89.36%，對照組為72.34%，兩組的總有效率有明顯差異（P<0.05）。治療后，兩組的視覺模擬評分法（VAS）評分明顯降低（P<0.05），且治療組VAS評分明顯低于對照組（P<0.05）。治療后，兩組的腫瘤壞死因子-α（TNF-α）、基質(zhì)金屬蛋白酶-9（MMP-9）、白細胞介素-8（IL-8）水平明顯降低（P<0.05）；治療后，治療組的TNF-α、MMP-9、IL-8比對照組低（P<0.05）。結(jié)論 丁細牙痛膠囊聯(lián)合鹽酸米諾環(huán)素軟膏治療慢性牙髓炎的療效確切，有助于提高療效，減輕患者疼痛程度，降低炎癥反應(yīng)，且安全性良好。

Objective To investigate the clinical efficacy of Dingxi Yatong Capsules combined with Minocycline Hydrochloride Ointments in treatment of chronic pulpitis. Methods Patients (94 cases) with chronic pulpitis in Tianjin Stomatological Hospital from June 2019 to January 2021 were randomly divided into control and treatment groups, and each group had 47 cases. Patients in the control group were smeared with Minocycline Hydrochloride Ointments, and the drug was sealed in the root canal, once daily. Patients in the treatment group were po administered with Dingxi Yatong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the degree of pain and the level of serum inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group was 89.36%, and that of the control group was 72.34%, and there was significant difference between the two groups (P<0.05). After treatment, the VAS score of two groups were significantly decreased (P<0.05), and the VAS score of the treatment group was significantly lower than that of the control group (P<0.05). After treatment, the levels of TNF-α, MMP-9, and IL-8 in two groups were significantly decreased (P<0.05). After treatment, the levels of TNF-α, MMP-9, and IL-8 in the treatment group were lower than those in the control group (P<0.05). Conclusion Dingxi Yatong Capsules combined with Minocycline Hydrochloride Ointments has clinical curative effect in treatment of chronic pulpitis, can help to improve the curative effect, reduce the degree of pain, reduce the inflammatory reaction, and has good safety.

R988.2

天津市口腔醫(yī)院博碩士重點青年項目（2019BSQN05）