雙相情感障礙是一種抑郁和躁狂兩極交替或混合發(fā)作的重性情感障礙，具有慢性、高復發(fā)性和高致殘性，因此受到了學者的極大關注。抗抑郁藥物的介入易使雙相情感障礙患者從抑郁轉為躁狂，其應用一直飽受質疑。因此從三環(huán)類抗抑郁藥、選擇性5-羥色胺再攝取抑制劑、去甲腎上腺素–多巴胺再攝取抑制劑、5-羥色胺和去甲腎上腺素再攝取抑制劑、單胺氧化酶抑制劑、褪黑激素類藥藥物類型方面綜述多種抗抑郁藥物在雙相情感障礙中的療效和安全性，闡述雙相情感障礙中抗抑郁藥物合理選擇的重要性和必要性。

Bipolar disorder is a kind of major affective disorder with alternate or mixed episodes of depression and mania. It has chronic, high recurrence and high disability, so it has attracted great attention from the researchers. The intervention of antidepressants can easily change bipolar disorder patients from depression to mania, and its application has been questioned. Therefore, the efficacy and safety of a variety of antidepressants in bipolar disorder were reviewed from the aspects of tricyclic antidepressants, selective serotonin reuptake inhibitors, norepinephrine dopamine reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, monoamine oxidase inhibitors and melatonin drugs, and the role of antidepressants in bipolar disorder was elaborated, and this article describes the importance and necessity of rational choice of antidepressants in bipolar disorder.

R964