目的 探討脈絡(luò)寧注射液聯(lián)合硫酸鎂注射液治療妊娠高血壓綜合征的臨床療效。方法 選擇2018年11月—2020年10月在鄭州市婦幼保健院西區(qū)就診的84例妊娠高血壓綜合征患者，按照隨機(jī)數(shù)字表法將84例患者分為對(duì)照組和治療組，每組各42例。對(duì)照組給予硫酸鎂注射液，首次劑量10 mL硫酸鎂注射液使用5%葡萄糖液稀釋至20 mL在5 min內(nèi)靜脈注射，然后給予60 mL硫酸鎂注射液加入500 mL的5%葡萄糖液充分稀釋，以1～2 g/h靜脈滴注，1次/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注脈絡(luò)寧注射液，10 mL加入250 mL的5%葡萄糖液，1次/d。兩組患者連續(xù)治療7 d。觀察兩組的臨床療效，比較兩組的血壓變化，檢測(cè)兩組治療前后血清白細(xì)胞介素-18（IL-18）、D-二聚體、同型半胱氨酸（Hcy）水平，隨訪記錄兩組的不良妊娠結(jié)局。結(jié)果 治療后，治療組患者的總有效率為90.48%，對(duì)照組的總有效率為73.81%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者的收縮壓和舒張壓均顯著降低（P<0.05），治療組的收縮壓和舒張壓較對(duì)照組降低的更明顯，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的IL-18、D-二聚體、Hcy水平明顯降低（P<0.05）；治療后，治療組的IL-18、D-二聚體、Hcy水平低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療組的產(chǎn)后出血、新生兒窒息、胎盤早剝、早產(chǎn)例數(shù)均少于對(duì)照組（P<0.05）。結(jié)論 脈絡(luò)寧注射液聯(lián)合硫酸鎂注射液可提高妊娠高血壓綜合征的療效，控制血壓，糾正血液高凝狀態(tài)，有助于改善妊娠結(jié)局。

Objective To investigate the clinical effect of Mailuoning Injection combined with Magnesium Sulfate Injection in treatment of pregnancy-induced hypertension syndrome. Methods Patients (84 cases) with pregnancy-induced hypertension syndrome in West District of Women & Infants Hospital of Zhengzhou from November 2018 to October 2020 were randomly divided into control and treatment groups, and each group had 42 cases. Patients in the control group were given Magnesium Sulfate Injection, the first dose of 10 mL magnesium sulfate injection was diluted to 20 mL with 5% glucose solution, and injected intravenously within 5 min, then 60 mL magnesium sulfate injection was given and diluted to 500 mL with 5% glucose solution, the injection was given intravenously at 1 — 2 g/h, once daily. Patients in the treatment group were po administered with Mailuoning Injection on the basis of the control group, 10 mL added into 5% glucose solution 500 mL, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, the changes of blood pressure of two groups were compared, and the serum levels of IL-18, D-dimer, and Hcy were detected before and after treatment. The adverse pregnancy outcomes of two groups were followed up. Results After treatment, the total effective rate of the treatment group was 90.48%, the control group was 73.81%, and the difference was statistically significant (P<0.05). After treatment, the systolic pressure and diastolic pressure of two groups were significantly decreased (P<0.05). And the blood pressure of the treatment group was more significantly lower than that of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of IL-18, D-dimer, and Hcy in two groups were significantly decreased (P<0.05). After treatment, the levels of IL-18, D-dimer, and Hcy in the treatment group were lower than those in the control group, and the difference was statistically significant (P<0.05). The postpartum hemorrhage, neonatal asphyxia, placental abruption and premature birth in the treatment group were lower than those in the control group (P<0.05). Conclusion Mailuoning Injection combined with Magnesium Sulfate Injection can improve the curative effect of pregnancy-induced hypertension syndrome, control blood pressure, correct blood hypercoagulability, and help to improve pregnancy outcome.

R984

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃省部共建項(xiàng)目（SB201901046）