目的 探討五淋化石丸聯(lián)合黃酮哌酯治療慢性非細(xì)菌性前列腺炎的臨床療效。方法 選取2018年1月—2020年1月在駐馬店市中心醫(yī)院泌尿一科住院治療的134例慢性非細(xì)菌性前列腺炎患者，隨機(jī)分成對(duì)照組（n=67）和治療組（n=67）。對(duì)照組口服鹽酸黃酮哌脂片，0.2 g/次，3次/d。治療組在對(duì)照組的基礎(chǔ)上口服五淋化石丸，5丸/次，3次/d。兩組均同時(shí)治療7 d。觀察兩組的臨床療效，比較兩組治療前后NIH-CPSI評(píng)分和血清炎性因子的變化情況。結(jié)果 治療后，治療組總有效率97.01%顯著高于對(duì)照組的74.63%（P<0.05）。治療后，兩組疼痛癥狀評(píng)分、排尿癥狀評(píng)分、生活質(zhì)量評(píng)分均顯著降低（P<0.05）；治療后，治療組NIH-CPSI評(píng)分顯著低于對(duì)照組（P<0.05）。治療后，兩組患者白細(xì)胞介素4（IL-4）、白細(xì)胞介素8（IL-8）、腫瘤壞死因子α（TNF-α）、干擾素γ（IFN-γ）水平均顯著降低（P<0.05）；治療后，治療組血清炎性因子水平低于對(duì)照組（P<0.05）。結(jié)論 五淋化石丸聯(lián)合黃酮哌酯治療慢性非細(xì)菌性前列腺炎臨床療效顯著，能有效改善尿頻、尿急、尿痛等癥狀，降低炎癥因子的水平，值得臨床借鑒與參考。

Objective To investigate the therapeutic effect of Wulin Huashi Pills combined with flavonolate in treatment of chronic abacterial prostatitis. Methods A total of 134 patients with chronic abacterial prostatitis who were hospitalized in the Department of Urology of Zhumadian Central Hospital from January 2018 to January 2020 were selected and randomly divided into control group (n=67) and treatment group (n=67). Patients in the control group were po administered with Flavoxate Hydrochloride Tablets, 0.2 g/time, three times daily. Patients in the treatment group were po administered with Wulin Huashi Pills on the basis of the control group, 5 pills/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the changes of NIH-CPSI scores and serum inflammatory factors were compared between the two groups before and after treatment. Results After treatment, the total effective rate of 97.01% in treatment group was significantly higher than that of 74.63% in control group (P<0.05). After treatment, pain symptom score, urination symptom score and quality of life score were significantly decreased in both groups (P<0.05). After treatment, the NIH-CPSI score in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the levels of interleukin 4 (IL-4), interleukin 8 (IL-8), tumor necrosis factor α (TNF-α), and interferon γ (IFN-γ) in two groups were significantly decreased (P<0.05). After treatment, the level of serum inflammatory factors in treatment group was lower than that in control group (P<0.05). Conclusion Wulin Huashi Pills combined with flavonolate has significant clinical effect in treatment of chronic abacterial prostatitis, and can effectively improve the symptoms of frequent urination, urgent urination and dysphoria, and reduce the level of inflammatory factors, which is worth clinical reference and reference.

R983

河南省科技攻關(guān)項(xiàng)目（201502161）