目的 觀察甘桔冰梅片聯(lián)合布地奈德吸入氣霧劑霧化吸入治療慢性咽炎的臨床療效。方法 選取2019年1月—2019年12月新鄉(xiāng)市第一人民醫(yī)院收治的100例慢性咽炎患者，參照隨機(jī)數(shù)字表法將患者分為對(duì)照組和治療組，每組各50例。對(duì)照組霧化吸入布地奈德吸入氣霧劑，0.5 mg/次，3次/d。治療組在對(duì)照組治療的基礎(chǔ)上口服甘桔冰梅片，2片/次，3次/d。兩組均以7 d為1個(gè)療程，持續(xù)治療3個(gè)療程。觀察兩組的臨床療效，比較兩組癥狀消失時(shí)間、血清炎癥因子水平。結(jié)果 治療后，對(duì)照組的總有效率為80.00%，治療組的總有效率為94.00%，治療組的臨床總有效率高于對(duì)照組（P<0.05）。治療后，治療組咽喉干癢、黏膜充血、聲音嘶啞和咽喉疼痛消失時(shí)間均短于對(duì)照組（P<0.05）。治療后，兩組血清白細(xì)胞介素-6（IL-6）和超敏C反應(yīng)蛋白（hs-CRP）水平較治療前降低（P<0.05），治療后治療組血清IL-6和hs-CRP水平較對(duì)照組低（P<0.05）。結(jié)論 甘桔冰梅片聯(lián)合布地奈德吸入氣霧劑霧化吸入治療慢性咽炎可促進(jìn)臨床癥狀改善，安全有效，其主要作用機(jī)制可能與降低炎癥因子水平有關(guān)。

Objective To observe the clinical effect of Ganju Bingmei Tablets combined with Budesonide Inhalation Aerosol in treatment of chronic pharyngitis. Methods Patients (100 cases) with chronic pharyngitis in Xinxiang First People’s Hospital from January 2019 to December 2019 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were atomization inhalation with Budesonide Inhalation Aerosol, 0.5 mg/time, three times daily. Patients in the treatment group were po administered with Ganju Bingmei Tablets on the basis of the control group, 2 tablets/time, three times daily. 7 days as A course of treatment, two groups of patients continued treatment for 3 courses. After treatment, the clinical efficacies were evaluated, and the levels of serum inflammatory factors and the disappearance time of symptoms were compared between two groups. Results After treatment, the total effective rate of the control group and the treatment group were 80.00% and 94.00%, and the total clinical effective rate of the treatment group was higher than that of the control group (P<0.05). After treatment, the disappearance time of dry throat itching, mucosal congestion, hoarseness and sore throat in the treatment group were shorter than those in the control group (P<0.05). After treatment, the serum levels of IL-6 and hs-CRP in two groups were lower than those before treatment (P<0.05), and the serum levels of IL-6 and hs-CRP in the treatment group were lower than those in the control group after treatment (P<0.05). Conclusion Ganju Bingmei Tablets combined with Budesonide Inhalation Aerosol in treatment of chronic pharyngitis can promote the improvement of clinical symptoms, with good safety, which main mechanism may be related to reduction of inflammatory factors.

R974

河南省科技發(fā)展計(jì)劃項(xiàng)目（18210211463）