目的 探討燈銀腦通膠囊聯(lián)合銀杏達(dá)莫注射液治療急性腦梗死的臨床療效。方法 選取2016年1月—2019年12月平煤神馬醫(yī)療集團(tuán)總醫(yī)院收治的180例急性腦梗死患者，隨機(jī)分為對(duì)照組和治療組，每組各90例。對(duì)照組靜脈滴注銀杏達(dá)莫注射液，25 mL加至500 mL生理鹽水中，2次/d。治療組在對(duì)照組治療的基礎(chǔ)上口服燈銀腦通膠囊，2粒/次，3次/d。兩組均連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組中醫(yī)證候積分、神經(jīng)功能缺損程度評(píng)分（NDS）、血清學(xué)指標(biāo)的變化情況。結(jié)果 治療后，治療組總有效率為97.78%，顯著高于對(duì)照組的74.44%（P<0.05）。治療后，兩組中醫(yī)證候積分、NDS評(píng)分均明顯比治療前低（P<0.05）；同時(shí)治療組治療后中醫(yī)證候積分、NDS評(píng)分均明顯比對(duì)照組低（P<0.05）。兩組治療后血清總膽固醇（TC）、低密度脂蛋白（LDL-C）、脂蛋白相關(guān)磷脂酶A2（Lp-PLA2）、超敏C反應(yīng)蛋白（hs-CRP）、腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-6（IL-6）水平均明顯比治療前低（P<0.05），同時(shí)治療組治療后這些指標(biāo)水平均明顯比對(duì)照組低（P<0.05）。結(jié)論 燈銀腦通膠囊聯(lián)合銀杏達(dá)莫注射液治療急性腦梗死的臨床療效顯著，能夠明顯減輕臨床癥狀，改善神經(jīng)功能缺損，調(diào)節(jié)血脂水平，抑制炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Dengyin Naotong Capsules combined with Ginkgo Leaf Extract and Dipyridamole Injection in treatment of acute cerebral infarction. Methods A total of 180 patients with acute cerebral infarction admitted to General Hospital of Pingmei Shenma Medical Group from January 2016 to December 2019 were selected and randomly divided into control group and treatment group, with 90 patients in each group. Patients in the control group were iv administered with Ginkgo Leaf Extract and Dipyridamole Injection, 25 mL added to 500 mL normal saline, twice daily. Patients in the treatment group were po administered with Dengyin Naotong Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the changes of TCM syndrome score, neurological deficit score (NDS) and serological indexes were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 97.78%, which was significantly higher than that of the control group (74.44%, P<0.05). After treatment, TCM syndrome score and NDS score in both groups were significantly lower than those before treatment (P<0.05). After treatment, the TCM syndrome score and NDS score in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, serum levels of TC, LDL-C, Lp-PLA2, hs-CRP, TNF-α, and IL-6 in two groups were significantly lower than before treatment (P<0.05). After treatment, the levels of these indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Dengyin Naotong Capsules combined with Ginkgo Leaf Extract and Dipyridamole Injection has significant clinical efficacy in treatment of acute cerebral infarction, and can significantly reduce clinical symptoms, also can improve neurological function defects, regulate blood lipid levels and inhibit inflammatory response, which has certain clinical application value.

R971

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃項(xiàng)目（2018020215）