目的 探討猴耳環(huán)消炎片聯(lián)合法莫替丁片治療急性胃腸炎的臨床療效。方法 選擇2019年4月—2020年4月在鄭州大學附屬鄭州中心醫(yī)院治療的急性腸胃炎患者84例，采用雙色球隨機分組法分成對照組與治療組，各42例。對照組口服法莫替丁片，20 mg/次，2次/d；治療組在對照組基礎上口服猴耳環(huán)消炎片，0.96 g/次，3次/d。兩組治療7 d。比較兩組臨床療效，觀察兩組臨床癥狀改善時間和血清學指標。結果 經治療，對照組患者有效率為80.95%，顯著低于治療組（97.62%，P<0.05）。經治療，治療組患者在腹痛、腹瀉、嘔吐等癥狀改善時間上均短于對照組（P<0.05）。經治療，兩組血清超敏C反應蛋白（hs-CRP）、白細胞介素-6（IL-6）、降鈣素原（PCT）、腫瘤壞死因子-α（TNF-α）水平均顯著下降（P<0.05），且治療后治療組血清學指標低于對照組（P<0.05）。結論 急性胃腸炎患者給予猴耳環(huán)消炎片和法莫替丁片共同治療不僅促進患者臨床癥狀改善，還有利于機體炎癥反應降低，有著良好的臨床應用價值。

Objective To explore the clinical effect of Houerhuan Xiaoyan Tablets combined with famotidine in treatment of acute gastroenteritis. Methods Patients (84 cases) with acute gastroenteritis in Zhengzhou Central Hospital Affiliated to Zhengzhou University from April 2019 to April 2020 were divided into control (42 cases) and treatment (42 cases) groups based on different treatments. Patients in the control group were po administered with Famotidine Tablets, 20 mg/time, twice daily. Patients in the treatment group were po administered with Houerhuan Xiaoyan Tablets on the basis of the control group, 0.96 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy of the two groups was compared, and the improvement time and serological indexes of the two groups were observed. Results After treatment, the clinical efficacy and in the control and treatment groups was 80.95% and 97.62% respectively, and there were differences between two groups (P<0.05). After treatment, the improvement time of abdominal pain, diarrhea and vomiting in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, serum levels of hs-CRP, IL-6, PCT and TNF-α in both groups were significantly decreased (P<0.05), and the serological indexes of the treatment group were lower than those of the control group (P<0.05). Conclusion Houerhuan Xiaoyan Tablets combined with famotidine in treatment of acute gastroenteritis can effectively improve the clinical symptoms, reduce inflammation, which has a certain clinical application value.

R975

河南省科學技術廳支撐基金項目（152102310006）