目的 探討大黃利膽膠囊聯(lián)合左氧氟沙星治療急性膽囊炎的臨床研究。方法 選取2019年3月-2020年3月在南陽市中心醫(yī)院治療的急性膽囊炎患者122例為研究對象，隨機分為對照組（61例）和治療組（61例）。對照組患者口服左氧氟沙星片，0.1 g/次，2~3次/d；治療組在對照組的基礎(chǔ)上口服大黃利膽膠囊，2粒/次，2~3次/d。兩組患者均治療14 d。觀察兩組患者臨床療效，同時比較治療前后兩組患者臨床癥狀，血清C反應(yīng)蛋白（CRP）、腫瘤壞死因子-α（TNF-α）、白細胞介素-6（1L-6）和1L-8水平及血液白細胞計數(shù)（WBC）、總膽紅素（TBIL）和淀粉酶（AMY）水平。結(jié)果 治療后，對照組和治療組臨床總有效率分別為78.69%和93.44%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組患者臨床癥狀恢復(fù)好轉(zhuǎn)時間均顯著早于對照組（P<0.05）。治療后，兩組患者CRP、TNF-α、1L-6、1L-8、WBC、TBIL和AMY水平均明顯降低（P<0.05）；且治療組顯著低于對照組（P<0.05）。結(jié)論 黃利膽膠囊聯(lián)合左氧氟沙星提高了臨床效果，縮短臨床癥狀的緩解時間，改善炎癥指標(biāo)，具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical efficacy of Dahuang Lidan Capsules combined with levofloxacin in treatment of acute cholecystitis. Methods Patients (122 cases) with acute cholecystitis in Nanyang Central Hospital from March 2019 to March 2020 were randomly divided into control (61 cases) and treatment (61 cases) groups. Patients in the control group were po administered with Levofloxacin Tablets, 0.1 g/time,2-3 time/d. Patients in the treatment group were po administered with Dahuang Lidan Capsules on the basis of the control group, 2 grains/time,2-3 time/d. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom, the levels of CRP, TNF-α, 1L-6, 1L-8, WBC, TBIL, and AMY in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 78.69% and 93.44% respectively, and there were differences between two groups (P<0.05). After treatment, the recovery time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, the levels of CRP, TNF-α, 1L-6, 1L-8, WBC, TBIL, and AMY in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Dahuang Lidan Capsules combined with levofloxacin in treatment of acute cholecystitis is effect, and can shorten the remission time of clinical symptoms, improve the inflammation indexes, which has a certain clinical application value.

R978

河南省高等學(xué)校青年骨干教師資助計劃項目（2014GGJS-187）