目的 探討苦丹丸聯(lián)合阿維A膠囊治療尋常型銀屑病的臨床療效。方法 選擇新鄉(xiāng)市中心醫(yī)院2019年11月-2020年4月收治的尋常型銀屑病患者96例，隨機(jī)分為對(duì)照組和治療組，每組各48例。對(duì)照組口服阿維A膠囊，20 mg/次，1次/d；治療組在對(duì)照組治療的基礎(chǔ)上口服苦丹丸，1袋/次，3次/d。兩組患者均治療8周。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者PASI評(píng)分、起效時(shí)間，及血清炎癥因子腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素17（IL-17）和白細(xì)胞介素23（IL-23）水平。結(jié)果 治療后，對(duì)照組和治療組臨床有效率分別為62.50%和83.33%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組PASI評(píng)分顯著降低（P<0.05），且治療組PASI評(píng)分降低更明顯（P<0.05），起效時(shí)間更短（P<0.05）。治療后，兩組TNF-α、IL-17、IL-23水平顯著降低（P<0.05），且治療組顯著低于對(duì)照組（P<0.05）。結(jié)論 苦丹丸聯(lián)合阿維A膠囊治療尋常型銀屑病臨床療效顯著，且安全性較高。

Objective To investigate the clinical efficacy of Kudan Pills combined with Acitretin Capsules in treatment of psoriasis vulgaris. Methods Patients (96 cases) with psoriasis vulgaris in Xinxiang Central Hospital from November 2019 to April 2020 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Acitretin Capsules, 20 mg/time, once daily. Patients in the treatment group were po administered with Kudan Pills on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the PASI scores, onset time and the serum inflammatory factors levels of TNF-α、IL-17 and IL-23 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 62.50% and 83.33% respectively, and there were differences between two groups (P<0.05). After treatment, the PASI scores in two groups were significantly decreased (P<0.05), and the PASI scores in the treatment group were significantly lower than those in the control group (P<0.05), the onset time in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the serum inflammatory factors levels of TNF-α、IL-17 and IL-23 in two groups were significantly decreased (P<0.05), and these factors levels in the treatment group were significantly lower than those in the control group (P<0.05). Conclusions Kudan Pills combined with Acitretin Capsules in treatment of psoriasis vulgaris is efficacy and safety.

R986