目的 觀察黃芩莖葉解毒膠囊聯(lián)合阿奇霉素治療急性咽炎的臨床效果。方法 選擇2017年4月—2019年6月在天津市泰達醫(yī)院治療的急性咽炎患者131例，隨機分為對照組（65例）和治療組（66例）。對照組口服阿奇霉素片，首日劑量0.5 g，第2～5天劑量為0.25 g。治療組在對照組的基礎(chǔ)上口服黃芩莖葉解毒膠囊，3粒/次，3次/d。兩組患者均連續(xù)治療5 d。觀察兩組患者臨床療效，同時比較治療前后兩組患者血清白細胞介素-6（IL-6）、C反應(yīng)蛋白（CRP）和IL-1β水平及臨床癥狀消失時間。結(jié)果 治療后，對照組和治療組臨床有效率分別為78.46%、93.94%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組IL-6、CRP和IL-1β水平均明顯降低（P<0.05），且治療組患者明顯低于對照組（P<0.05）。治療后，治療組患者臨床癥狀消失時間明顯比對照組短（P<0.05）。結(jié)論 黃芩莖葉解毒膠囊聯(lián)合阿奇霉素治療急性咽炎，可快速改善患者臨床癥狀，緩解機體炎癥反應(yīng)水平。

Objective To observe the clinical effect of Huangqin Jingye Jiedu Capsules combined with azithromycin in treatment of acute pharyngitis. Methods Patients (131 cases) with acute pharyngitis in Tianjin TEDA Hospital from April 2017 to June 2019 were randomly divided into control (65 cases) and treatment (66 cases) groups. Patients in the control group were po administered with Azithromycin Tablets, the first day dose was 0.5 g, 0.25 g for the 2nd day to the fifth day. Patients in the treatment group were po administered with Huangqin Jingye Jiedu Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the serum levels of IL-6, CRP and IL-1β, and the disappearance time of clinical symptoms in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 78.46% and 93.94%, respectively, and there were differences between two groups (P<0.05). After treatment, the serum levels of IL-6, CRP and IL-1β in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the disappearance time of clinical symptoms in the treatment group were significantly earlier than that in the control group (P<0.05). Conclusion Huangqin Jingye Jiedu Capsules combined with azithromycin in treatment of acute pharyngitis can rapidly improve the clinical symptoms, and relieve the level of inflammatory response.

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