目的 研究銀杏達(dá)莫注射液聯(lián)合注射用鼠神經(jīng)生長(zhǎng)因子治療重型急性顱腦損傷的臨床療效。方法 選取2016年8月—2020年3月焦作同仁醫(yī)院接受治療的75例重型急性顱腦損傷患者，將所有患者隨機(jī)分為對(duì)照組（38例）和治療組（37例）。對(duì)照組患者肌肉注射注射用鼠神經(jīng)生長(zhǎng)因子，30 μg加入到0.9%氯化鈉注射液2 mL，1次/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注銀杏達(dá)莫注射液，10 mL加入0.9%氯化鈉注射液500 mL中，2次/d。兩組患者接受治療時(shí)間為2周。觀察兩組患者臨床療效，比較兩組的簡(jiǎn)易智力狀態(tài)檢查量表（MMSE）評(píng)分、格拉斯哥昏迷（GCS）評(píng)分、美國(guó)國(guó)立衛(wèi)生研究院卒中量表（NIHSS）評(píng)分、血清腫瘤壞死因子-α（TNF-α）和白細(xì)胞介素-6（IL-6）、神經(jīng)元特異性烯醇化酶（NSE）和S100β水平。結(jié)果 治療后，治療組總有效率94.74%顯著高于對(duì)照組的78.38%（P<0.05）。治療后，兩組MMSE評(píng)分和GCS評(píng)分明顯升高，NIHSS評(píng)分明顯降低（P<0.05），且治療組改善程度較大（P<0.05）。治療后，兩組血清TNF-α、IL-6、NSE和S100β蛋白水平顯著降低（P<0.05）；并且治療組降低較明顯（P<0.05）。結(jié)論 銀杏達(dá)莫注射液聯(lián)合注射用鼠神經(jīng)生長(zhǎng)因子治療重型急性顱腦損傷具有較好的療效，可改善患者認(rèn)知功能，降低腦損傷程度，降低血清因子水平。

Objective To study the efficacy of Ginkgo Leaf Extract and Dipyridamole Injection combined with Mouse Nerve Growth Factor for injection in treatment of severe acute craniocerebral injury. Methods Patients (75 cases) with severe acute craniocerebral injury in Jiaozuo Tongren Hospital from August 2016 to March 2020 were randomly divided into the control group (38 cases) and the treatment group (37 cases). Patients in the control group were iv administered with Mouse Nerve Growth Factor for injection, 30 μg added into normal saline 2 mL, once daily. Patients in the treatment group were iv administered with Ginkgo Leaf Extract and Dipyridamole Injection on the basis of the control group, 10 mL added into normal saline 500 mL, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and MMSE score, GCS score, NIHSS score, the serum levels of TNF-α, IL-6, NSE, and S100β in two groups were compared. Results After treatment, the total effective rate of the treatment group was 94.74%, which was significantly higher than 78.38% of the control group (P<0.05). After treatment, the MMSE score and the GCS score of two groups were significantly increased, but the NIHSS score of two groups was significantly decreased (P<0.05), and the improvement degree of the treatment group was better than that of the control group (P<0.05). After treatment, the serum levels of TNF-α, IL-6, NSE, and S100β protein in two groups were significantly decreased (P<0.05), and the observational indexes of the treatment group was significantly lower than those in the control group (P<0.05). Conclusion Ginkgo Leaf Extract and Dipyridamole Injection combined with Mouse Nerve Growth Factor for injection has clinical curative effect in treatment of severe acute craniocerebral injury, can improve the cognitive function of patients, reduce the degree of brain injury, and reduce the level of serum factors.

R971