目的 探討克癢舒洗液聯(lián)合雙唑泰栓治療外陰陰道假絲酵母菌病的臨床療效。方法 選取2019年4月—2020年4月在汝州市第一人民醫(yī)院進行治療的80例外陰陰道假絲酵母菌病患者為研究對象，根據(jù)就診順序分為對照組（40例）和治療組（40例）。對照組給予雙唑泰栓，睡前將1枚送入陰道深處，1次/d；治療組在對照組基礎上給予克癢舒洗液，每次33 mL，用66 mL溫水稀釋后放入100 mL沖洗器內，沖洗陰道，1次/d。兩組均進行7 d治療。觀察兩組的臨床療效，比較兩組治療前后相關評分、血清學指標、陰道菌群指標的變化情況。結果 治療后，治療組總有效率97.50%，顯著高于對照組的80.00%（P<0.05）。治療后，兩組臨床癥狀評分顯著降低，而QLQ-C30評分均顯著升高（P<0.05）；治療后，治療組臨床癥狀評分顯著低于對照組，而QLQ-C30評分顯著高于對照組（P<0.05）。治療后，兩組血清白細胞介素-6（IL-6）、白細胞介素-13（IL-13）、人單核細胞趨化蛋白-1（MCP-1）、腫瘤壞死因子-α（TNF-α）較治療前顯著降低，但白細胞介素-12（IL-12）水平顯著升高（P<0.05）；但治療后，治療組這些血清學指標優(yōu)于對照組（P<0.05）。治療后，兩組患者菌落≥1/2面積率、陰道菌群糾正率均較治療前顯著提高（P<0.05）；治療后，治療組患者這些陰道菌群指標顯著優(yōu)于對照組（P<0.05）。結論 克癢舒洗液聯(lián)合雙唑泰栓治療外陰陰道假絲酵母菌病具有較好的臨床療效，可有效改善患者相關癥狀，糾正陰道菌群紊亂，改善機體血清細胞因子水平，提高患者生活質量，具有一定的臨床推廣應用價值。

Objective To investigate the clinical effect of Keyangshu Lotion combined with Metronidazole, Clotrimazole and Chlorhexidine Acetate Suppositories in treatment of vulvovaginal candidiasis. Methods 80 Patients with vulvovaginal candidiasis who were treated in the First People's Hospital of Ruzhou from April 2019 to April 2020 were selected as the research objects, and they were divided into control group (40 cases) and treatment group (40 cases) according to the order of treatment. The control group was given Metronidazole, Clotrimazole and Chlorhexidine Acetate Suppositories, put 1 tablet deep into the vagina before going to bed, once daily. The treatment group was given Keyangshu Lotion on the basis of the control group, 33 mL each time diluted with 66 mL warm water and then put into a 100 mL rinser to rinse the vagina, once daily. Both groups received treatment for 7 days. The clinical efficacy of the two groups was observed, and the changes of relevant scores, serological indexes and vaginal microflora indexes before and after treatment were compared between the two groups. Results After treatment, the total effective rate of 97.50% in the treatment group was significantly lower than 80.00% in the control group (P<0.05). After treatment, the clinical symptom scores of the two groups were significantly decreased, while the QLQ-C30 scores were significantly increased (P<0.05). After treatment, the clinical symptom score of the treatment group was significantly lower than that of the control group, while the QLQ-C30 score was significantly higher than that of the control group (P<0.05). After treatment, the levels of interleukin-6 (IL-6), interleukin-13 (IL-13) and human monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor (TNF-α) in the two groups were significantly lower than those before treatment, but the level of interleukin-12 (IL-12) was significantly higher in the two groups (P<0.05). However, after treatment, these serological indicators in the treatment group were superior to those in the control group (P<0.05). After treatment, the bacterial colony ≥ 1/2 area rate and the correction rate of vaginal microflora in both groups were significantly increased compared with those before treatment (P<0.05). After treatment, these vaginal microflora indexes in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Keyangshu Lotion combined with Metronidazole, Clotrimazole and Chlorhexidine Acetate Suppositories has good clinical effect in treatment of vulvovaginal candidiasis, and can effectively improve the related symptoms, and can correct the disturbance of vaginal flora, and improve the serum cytokine levels, and improve the life quality of patients, which has a certain clinical application value.

R984

河南省醫(yī)學科技攻關計劃項目（201702366）