目的 探討調(diào)經(jīng)促孕丸聯(lián)合鹽酸二甲雙胍片治療肥胖型多囊卵巢綜合征不孕患者的臨床療效。方法 選取2018年1月-2019年6月南陽(yáng)市中心醫(yī)院收治的肥胖型多囊卵巢綜合征不孕癥患者190例為研究對(duì)象，按照隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組，每組各95例。對(duì)照組口服鹽酸二甲雙胍片，100 mg/次，2次/d。治療組則在對(duì)照組的基礎(chǔ)上口服調(diào)經(jīng)促孕丸，5 g/次，2次/d。兩組均以7 d為1個(gè)療程，連續(xù)用藥3個(gè)療程后停止用藥，待下個(gè)經(jīng)期第5天后再次用藥3個(gè)療程。兩組均治療3個(gè)月經(jīng)周期。觀察兩組患者臨床療效，比較兩組的激素指標(biāo)、排卵率、妊娠率。結(jié)果 治療后，治療組的臨床總有效率為88.42%，高于對(duì)照組的76.84%（P<0.05）。治療后，兩組睪酮（T）、促黃體生成素（LH）、卵泡刺激素（FSH）水平均顯著下降（P<0.05），且治療組的激素水平明顯低于對(duì)照組（P<0.05）。治療后，治療組的排卵率、妊娠率均高于對(duì)照組（P<0.05）。結(jié)論 調(diào)經(jīng)促孕丸聯(lián)合鹽酸二甲雙胍片治療肥胖型多囊卵巢綜合征不孕的療效顯著，可改善機(jī)體激素水平，提高排卵率、妊娠率。

Objective To explore the clinical effect of Tiaojing Cuyun Pills combined with Metformin Hydrochloride Tablets in treatment of infertility of obese polycystic ovary syndrome. Methods Patients (190 cases) with infertility of obese polycystic ovary syndrome in Nanyang Central Hospital from January 2018 to June 2019 were randomly divided into control and treatment groups, and each group had 95 cases. Patients in the control group were po administered with Metformin Hydrochloride Tablets, 100 mg/time, twice daily. Patients in the treatment group were po administered with Tiaojing Cuyun Pills on the basis of the control group, 5 g/time, twice daily. A course of treatment had 7 d, and patients in two groups were stopped taking drugs after 3 courses of treatment. And at the fifth day of the next menstrual period, the drug was given again for 3 courses. Patients in two groups were treated for 3 menstrual cycles. After treatment, the clinical efficacies were evaluated, and hormone indexes, ovulation rate and pregnancy rate in two groups were compared. Results After treatment, the clinical total effective rate of the treatment group was 88.42%, which was higher than 76.84% of the control group (P < 0.05). After treatment, the levels of testosterone (T), luteinizing hormone (LH), and follicle stimulating hormone (FSH) in two groups were significantly decreased (P < 0.05), and the hormone levels in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the ovulation rate and pregnancy rate in the treatment group were higher than those in the control group (P < 0.05). Conclusion Tiaojing Cuyun Pills combined with Metformin Hydrochloride Tablets has clinical curative effect in treatment of infertility of obese polycystic ovary syndrome, can improve hormone level, ovulation rate and pregnancy rate.

R984

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃項(xiàng)目（201602371）