目的 探討齒痛消炎靈聯(lián)合多西環(huán)素治療慢性牙周炎的臨床療效。方法 選取2019年5月-2020年5月濮陽市第三人民醫(yī)院收治的慢性牙周炎患者110例（139顆患牙），隨機(jī)分為對(duì)照組（55例69顆牙）和治療組（55例70顆牙）。對(duì)照組口服鹽酸多西環(huán)素片，0.1 g/次，1次/d；治療組在對(duì)照組基礎(chǔ)上口服齒痛消炎靈顆粒，10 g/次，3次/d。兩組均連續(xù)治療4周。比較兩組的臨床療效，觀察兩組牙周指標(biāo)、外周血細(xì)胞因子水平、基質(zhì)金屬蛋白酶2（MMP-2）、基質(zhì)金屬蛋白酶組織抑制因子2（TIMP-2）的變化情況。結(jié)果 治療后，治療組的總有效率是94.55%，顯著高于對(duì)照組的78.18%（P<0.05）。治療后，兩組口腔內(nèi)牙周袋深度（PD）、菌斑指數(shù)（PLI）、出血指數(shù)（BI）、附著喪失（AL）和牙槽骨吸收（ABL）顯著低于同組治療前（P<0.05）；治療組治療后這些牙周指標(biāo)明顯低于對(duì)照組（P<0.05）。治療后，兩組患者TNF-α、IL-6和HMGB水平明顯低于同組治療前，而IL-10顯著提高（P<0.05）；治療組治療后這些外周血中細(xì)胞因子水平改善優(yōu)于對(duì)照組（P<0.05）。治療后，兩組MMP-2、TIMP-2、MMP-2/TIMP-2比值明顯低于同組治療前水平（P<0.05）；治療后治療組MMP-2、TIMP-2、MMP-2/TIMP-2比值明顯低于對(duì)照組（P<0.05）。結(jié)論 齒痛消炎靈聯(lián)合多西環(huán)素治療慢性牙周炎療效明顯，可有效地降低炎癥水平，從根本上改善牙周指標(biāo)和基質(zhì)金屬蛋白酶，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the curative effect of Chitong Xiaoyanling Granules combined with doxycycline in treatment of chronic periodontitis. Methods 110 Patients (139 teeth) with chronic periodontitis admitted to the Third People's Hospital of Puyang from May 2019 to May 2020 were randomly divided into the control group (55 cases with 69 teeth) and the treatment group (55 cases with 70 teeth). The control group was po administered with Doxycycline Hyclate Tablets 0.1 g/time, once daily. The treatment group was po administered with Chitong Xiaoyanling Granules on the basis of the control group, 10 g/time, 3 times daily. Both groups were treated continuously for 4 weeks. The clinical efficacy of the two groups was compared, and the changes of periodontal indexes, peripheral blood cytokine levels, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase tissue inhibitor-2 (TIMP-2) in the two groups were observed. Results After treatment, the total effective rate of the treatment group was 94.55%, significantly higher than that of the control group 78.18% (P < 0.05). After treatment, the periodontal pocket depth (PD), plaque index (PLI), bleeding index (BI), attachment loss (AL) and alveolar bone resorption (ABL) in the two groups were significantly better than those before treatment (P < 0.05). These periodontal indexes in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and high mobility group protein B (HMGB) in the two groups were significantly lower than those before treatment, but IL-10 was significantly higher (P < 0.05). After treatment, the level of cytokines in peripheral blood of the treatment group was better than that of the control group. After treatment, the MMP-2, TIMP-2 and MMP-2/TIMP-2 ratios in the two groups were significantly lower than those before treatment (P < 0.05). After treatment, the MMP-2, TIMP-2 and MMP-2/TIMP-2 ratios in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Chitong Xiaoyanling Granules combined with doxycycline has obvious curative effect in treatment of chronic periodontitis, and can effectively reduce inflammation levels, and also can fundamentally improve periodontal indexes and matrix metalloproteinase, which has a certain clinical application value.

R988.2

濮陽市科技計(jì)劃項(xiàng)目（1805076）