目的 探討強力定眩片聯(lián)合氟桂利嗪治療腦動脈硬化性眩暈的臨床療效。方法 選取2017年3月-2019年12月天津市寧河區(qū)醫(yī)院收治的腦動脈硬化性眩暈患者120例，隨機分為對照組（60例）和治療組（60例）。對照組口服鹽酸氟桂利嗪膠囊，65歲以下患者10 mg/次，65歲以上患者5 mg/次，1次/d，每周給藥5 d。治療組在對照組的基礎上口服強力定眩片，4片/次，3次/d。兩組均治療2個月。觀察兩組患者臨床療效，同時比較治療前后兩組患者癥狀評分，及右椎動脈、左椎動脈和基底動脈的平均血流速度。結果 治療后，對照組臨床有效率為76.67%，顯著低于治療組的91.67%，兩組比較差異有統(tǒng)計學意義（P<0.05）。治療后，兩組患者植物神經功能紊亂、聽力障礙、眩暈、平衡障礙、頭痛、耳鳴癥狀評分均明顯下降（P<0.05），且治療組明顯低于對照組（P<0.05）。治療后，兩組患者右椎動脈、左椎動脈和基底動脈的平均血流速度均顯著升高（P<0.05），且治療組明顯高于對照組（P<0.05）。結論 強力定眩片聯(lián)合氟桂利嗪治療腦動脈硬化性眩暈，可迅速改善患者臨床癥狀及腦血流狀況，具有一定的臨床推廣應用價值。

Objective To investigate the clinical effect of Qiangli Dingxuan Tablets combined with flunarizine in treatment of cerebral arteriosclerotic vertigo. Methods Patients (120 cases) with cerebral arteriosclerotic vertigo in Tianjin Ninghe Hospital from March 2017 to December 2019 were randomly divided into control (60 cases) and treatment (60 cases) groups. Patients in the control group were po administered with Flunarizine Hydrochloride Capsules, 10 mg/time for less than 65 years old, and 5 mg/time for more than 65 years, once daily, 5 times/weekly. Patients in the treatment group were po administered with Qiangli Dingxuan Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacy was evaluated, and the symptom scores, and the mean flow velocity of the right vertebral artery, left vertebral artery and basilar artery in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 76.67%, which was significantly lower than 91.67% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the symptom scores of dysfunction of the vegetative nerve, hearing impairment, vertigo, balance disorders, headache and tinnitus in two groups were significantly decreased (P < 0.05), and these scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the mean flow velocity of the right vertebral artery, left vertebral artery and basilar artery in two groups was significantly increased (P < 0.05), and which in the treatment group was significantly higher than that in the control group (P < 0.05). Conclusion Qiangli Dingxuan Tablets combined with flunarizine in treatment of cerebral arteriosclerotic vertigo can rapidly improve the clinical symptoms and cerebral blood flow, which has a certain clinical application value.

R971

天津市科技計劃項目（15ZXMFCY00062）