目的 探討抗宮炎片聯(lián)合左氧氟沙星片治療慢性盆腔炎的臨床療效。方法 選取2017年7月-2018年7月焦作市第二人民醫(yī)院收治的126例慢性盆腔炎性疾病患者作為研究對(duì)象，將所有患者隨機(jī)分為對(duì)照組和治療組，每組各63例。對(duì)照組患者口服左氧氟沙星片，1片/次，1次/d。治療組在對(duì)照組的基礎(chǔ)上口服抗宮炎片，3片/次，3次/d。兩組患者持續(xù)治療2周。觀察兩組患者的臨床療效，比較兩組的臨床癥狀消退時(shí)間、炎癥因子水平。結(jié)果 治療后，治療組的總有效率為95.24%，高于對(duì)照組的85.71%，組間差異顯著（P<0.05）。治療后，治療組患者白帶復(fù)常時(shí)間、盆腔腫塊消失時(shí)間、下腹墜脹消失時(shí)間、炎性滲出消失時(shí)間、腹痛緩解時(shí)間均明顯短于對(duì)照組（P<0.05）。治療后，兩組患者腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素（IL）-1β、超敏C-反應(yīng)蛋白（hs-CRP）水平均顯著降低，IL-10、IL-4水平明顯升高，組內(nèi)差異顯著（P<0.05），治療后治療組的各指標(biāo)改善水平明顯優(yōu)于對(duì)照組，組間差異顯著（P<0.05）。結(jié)論 抗宮炎片聯(lián)合左氧氟沙星片治療慢性盆腔炎的療效確切，能降低患者的臨床癥狀消失時(shí)間，抑制炎癥，值得臨床推廣。

Objective To investigate the clinical efficacy of Kanggongyan Tablets combined with Levofloxacin Tablets in treatment of chronic pelvic inflammatory disease. Methods Patients (126 cases) with chronic pelvic inflammatory disease in Jiaozuo Second People's Hospital from July 2017 to July 2018 were randomly divided into control and treatment groups, and each group had 63 cases. Patients in the control group were po administered with Levofloxacin Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Kanggongyan Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptoms subsided time and the serum levels of inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.24%, which was higher than 85.71% of the control group (P<0.05). After treatment, the leucorrhea recovery time, pelvic mass disappearance time, abdominal distention disappeared time, inflammatory exudation time and abdominal pain relief time in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of TNF-α, IL-1β, and hs-CRP in the two groups were decreased, but the levels of IL-10 and IL-4 were increased (P<0.05). After treatment, the improvement of these indexes in the treatment group was better than those in the control group (P<0.05). Conclusion Kanggongyan Tablets combined with Levofloxacin Tablets has clinical curative effect in treatment of chronic pelvic inflammatory disease, can reduce the disappearance time of clinical symptoms, and inhibit inflammation, which is worthy of clinical promotion.

R984

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃聯(lián)合共建項(xiàng)目（LHGJ20191350）