近年來，冠狀病毒感染人體事件頻繁發(fā)生，給人類造成了巨大損失。新型冠狀病毒（SARS-CoV-2）不僅傳播迅速，而且具有致命性，目前已構成全球大流行，導致了數(shù)十萬人的死亡。因此SARS-CoV-2的及時診療十分重要。由于冠狀病毒的結構蛋白在病毒復制感染傳播過程中發(fā)揮重要作用，所以綜述了基于此次SARS-CoV-2 4種結構蛋白S、E、M、N的相關診斷治療預防技術的研究進展，為更好地深入了解冠狀病毒的致病機制以及為臨床檢出和藥物疫苗研發(fā)提供有力支持。

In recent years, coronavirus infections have occurred frequently, causing huge losses to humans. The new coronavirus (SARS-CoV-2) not only spread rapidly, but is also lethal. It has now constituted a global pandemic, resulting in the death of hundreds of thousands of people. Therefore, the timely diagnosis and treatment of new coronavirus is very important. Since coronavirus structural proteins play an important role in the process of viral replication, infection and transmission. The research progress on diagnostic, therapeutic and prevention technologies based on this new coronavirus structural proteins S, E, M, and N is reviewed in this paper, in order to better understand the pathogenic mechanism of coronavirus as well as provide strong support for clinical detection, drug development, and vaccine preparation.

R974

國家自然科學基金青年科學基金資助項目（21907007）；北京市自然科學基金青年項目（2204088）