目的 分析2014—2018年天津市腫瘤醫(yī)院門診麻醉性鎮(zhèn)痛藥的使用情況，為臨床合理使用提供參考。方法 調(diào)取天津市腫瘤醫(yī)院2014—2018年門診麻醉性鎮(zhèn)痛藥的用藥相關信息，對藥物劑型、使用金額、用藥頻度（DDDs）、日均費用（DDC）及藥品排序比（B/A）進行統(tǒng)計分析。結(jié)果 2014—2018年門診麻醉性鎮(zhèn)痛藥中，口服劑型的使用金額和DDDs的構(gòu)成比逐年上漲，透皮貼劑和注射劑使用金額和DDDs的構(gòu)成比呈下降趨勢。硫酸嗎啡緩釋片30 mg的DDDs排名一直居于首位，羥考酮緩釋片10 mg在2016年后上升至第2位，羥考酮緩釋片40 mg排名大幅上升，芬太尼透皮貼劑8.4 mg的DDDs排名出現(xiàn)明顯下降。2016—2017年各麻醉性鎮(zhèn)痛藥的DDC開始略有下降。各藥品的B/A略有變化，均接近1，表明使用金額與使用頻度的同步性較好。結(jié)論 天津市腫瘤醫(yī)院麻醉性鎮(zhèn)痛藥的使用合理，符合安全、有效、方便的原則。

Objective To investigate the utilization of narcotic analgesics in the outpatients of Tianjin Cancer Hospital from 2014 to 2018. Methods The utilization information of narcotic analgesics in the outpatients of Tianjin Cancer Hospital from 2014 to 2018 was extracted, and the dosage form of drugs, consumption sum, defined daily doses (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) were analyzed statistically. Results From 2014 to 2018, the consumption and DDDs constituent ratios of oral formulations had increased sharply. The consumption and DDDs constituent ratios of transdermal patches and injections had been on a downward trend. In the past five years, the DDDs of morphine sulfate sustained release tablet (30 mg) led the list. By 2016, the DDDs of Oxycodone Sustained-release Tablets (10 mg) ranked the second. DDDs of Oxycodone Sustained-release Tablets (40 mg) increased significantly, while Fentanyl Transdermal Patches (8.4 mg) declined obviously. DDC of various narcotic analgesics began to decline slightly from 2016 to 2017. B/A of most fluorouracil drugs closed to 1.00, indicating that the synchronism was better. Conclusion The utilization of narcotic analgesics in Tianjin Cancer Hospital is reasonable, accords with the principle of safety, effectiveness and convenience.

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