目的 研究心脈隆注射液聯(lián)合尼可地爾治療老年低射血分數(shù)慢性心力衰竭（HFrEF）的臨床效果。方法 選取2016年2月—2018年2月新鄉(xiāng)市第一人民醫(yī)院低射血分數(shù)慢性心力衰竭患者124例，隨機分為對照組和治療組，每組各62例。對照組口服尼可地爾片，5 mg/次，3次/d。治療組在對照組基礎(chǔ)上給予心脈隆注射液，5 mg/kg加入生理鹽水100 mL于皮試后靜脈滴注，2次/d。兩組均連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組治療前后左室結(jié)構(gòu)和功能指標(biāo)、6 min步行試驗（6MWT）的變化情況。結(jié)果 治療后，對照組和治療組總有效率分別是80.65%、93.55%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組左室舒張末期內(nèi)徑（LVEDD）和收縮末期內(nèi)徑（LVESD）均明顯降低（P<0.05），而兩組左室射血分數(shù)（LVEF）明顯升高（P<0.05）；且治療后治療組LVEDD和LVESD低于對照組，而LVEF高于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 心脈隆注射液聯(lián)合尼可地爾治療低射血分數(shù)慢性心力衰竭效果良好，可明顯改善患者心功能和活動能力，具有一定的臨床推廣應(yīng)用價值。

Objective To study the clinical effects of Xinmailong Injection combined with nicorandil in treatment of elderly chronic heart failure with reduced ejection fraction. Methods A total of 124 patients with chronic heart failure with reduced ejection fraction in Xinxiang First People's Hospital from February 2016 to February 2018 were randomly divided into control group (n=62) and treatment group (n=62). The control group was po administered with Nicorandil Tablets, 5 mg/time, three times daily. The treatment group was given Xinmailong Injection on the basis of the control group, 5 mg/kg added into 100 mL normal saline to intravenous drip after skin test, 5 mg/time, twice daily. All patients were treated for 14 days. The clinical efficacy were compared, the changes of left ventricular structure and functional indicators, 6 min walking test (6MWT) before and after treatment were compared between the two groups. Results The effective rates in control and treatment groups were 80.65% and 93.55%, respectively, and the difference between the two groups was statistically significant (P<0.05). After treatment, LVEDD and LVESD decreased significantly in both groups (P<0.05), while LVEF increased significantly in both groups (P<0.05). After treatment, LVEDD and LVESD in the treatment group were lower than those in the control group, while LVEF was higher than that in the control group. The difference between the two groups was statistically significant (P<0.05). Conclusion Xinmailong Injection combined with nicorandil has good effects in treatment of chronic heart failure with reduced ejection fraction, and it can significantly improve the heart function and activity ability, which has a certain clinical application value.

R972