目的 調查頭孢西丁致過敏性休克的報道情況，為臨床安全用藥及開展藥學監(jiān)護提供依據(jù)。方法 檢索中文科技期刊全文數(shù)據(jù)庫（維普）、中國學術期刊（網(wǎng)絡版）、萬方數(shù)字化期刊全文庫，以"頭孢西丁"和"過敏性休克"為標題檢索詞，對1999年1月-2019年10月關于頭孢西丁致過敏性休克的報道進行統(tǒng)計、分析。結果 共檢索到17篇文獻，結合本院1例，共計22例病例。包括男性9例，女性13例，平均年齡41歲；預防性用藥6例，治療性用藥16例。消化系統(tǒng)疾病、呼吸系統(tǒng)疾病構成比分別為45.5%、31.8%。靜脈滴注21例，靜脈推注1例；在治療性用藥中有6例聯(lián)合用藥，其余均為單獨用藥。過敏性休克發(fā)生時間小于30 min的有19例，大于30 min有3例。結論 醫(yī)療機構對頭孢西丁所致過敏性休克必須引起重視，加強臨床合理用藥，用藥期間積極開展藥學監(jiān)護。

Objective To investigate the occurrence of anaphylactic shock induced by cefoxitin so as to provide a reference for safe medication and pharmaceutical care. Methods Literatures about anaphylactic shock induced by cefoxitin were collected from Chinese Science and Technology Journal Full-text Database (VIP), Chinese Academic Journal (online), and Wangfang Database from 1999 to 2019, and the data was analyzed statistically. Results A total of 17 literatures involving 22 patients were collected with 9 men and 13 women. The average age was 41 years old. Diseases of digestive system and respiratory system accounted for 45.5% and 31.8%. Cefoxitin was used to preventive infection in 6 patients while the rest 16 were therapeutic infection. 21 Patients were take medication by intravenous drips. Cefoxitin was combined with the other drugs to prevention Infection for 6 cases, and the others were used alone. Anaphylactic shock was happened less than 30 minutes for 19 cases and more than 30 minutes for 3 cases. Conclusion The medical institutions should pay attention to the anaphylactic shock caused by cefoxitin, and the clinical rational use of drugs should be strengthened, and pharmaceutical care should be actively carried out.

R978.1

攀枝花市級指導性科技計劃項目（2019ZD-S-41）