目的 分析丹紅化瘀口服液聯(lián)合卵磷脂絡(luò)合碘治療視網(wǎng)膜靜脈阻塞的的臨床效果。方法 選擇2016年2月-2019年2月在鄭州大學(xué)附屬鄭州中心醫(yī)院治療的視網(wǎng)膜靜脈阻塞患者105例，隨機(jī)分成對(duì)照組（52例）和治療組（53例）。對(duì)照組口服卵磷脂絡(luò)合碘片，2片/次，3次/d。治療組在對(duì)照組的基礎(chǔ)上口服丹紅化瘀口服液，20 mL/次，3次/d。兩組患者均治療3個(gè)月。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者搏動(dòng)指數(shù)（PI）、阻力指數(shù)（RI）、舒張末期血流速度（EDV）和收縮峰值血流速度（PSV）水平及血清可溶性細(xì)胞間黏附分子-1（ICAM-1）、單核細(xì)胞趨化蛋白-1（MCP-1）和腫瘤壞死因子-α（TNF-α）水平。結(jié)果 治療后，對(duì)照組臨床有效率為75.00%，顯著低于治療組的94.34%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組PI和RI水平明顯降低（P<0.05），而EDV和PSV指標(biāo)水平均明顯升高（P<0.05），且治療組PI、RI、EDV和PSV等指標(biāo)改善效果明顯優(yōu)于對(duì)照組（P<0.05）。治療后，兩組ICAM-1、MCP-1、TNF-α指標(biāo)均明顯降低（P<0.05），且治療組明顯低于對(duì)照組（P<0.05）。結(jié)論 丹紅化瘀口服液聯(lián)合卵磷脂絡(luò)合碘治療視網(wǎng)膜靜脈阻塞，可改善眼部血液循環(huán)，臨床療效較好，安全可靠。

Objective To analyze the clinical effect of Danhong Huayu Oral Liquid combined with iodized lecithin in treatment of retinal vein occlusion. Methods Patients (105 cases) with retinal vein occlusion in Zhengzhou Central Hospital Affiliated to Zhengzhou University from February 2016 to February 2019 were randomly divided into control (52 cases) and treatment (53 cases) groups. Patients in the control group were po administered with Iodized Lecithin Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Danhong Huayu Oral Liquid on the basis of the control group, 20 mL/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the level of PI, RI, EDV, PSV, ICAM-1, MCP-1, and TNF-α in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the control group was 75.00%, which was significantly lower than 94.34% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the level of PI and RI in two groups was significantly decreased (P<0.05), but the EDV and PSV level was significantly increased (P<0.05), and the level of PI, RI, EDV and PSV in the treatment group was significantly better than that in the control group (P<0.05). After treatment, the level of ICAM-1, MCP-1 and TNF-α in two groups was significantly decreased (P<0.05), and which in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Danhong Huayu Oral Liquid combined with iodized lecithin in treatment of retinal vein occlusion can improve ocular blood circulation, which has good clinical efficacy, safety and reliability.

R971

河南省醫(yī)學(xué)科技攻關(guān)項(xiàng)目（2018020799）