目的 探討千柏鼻炎片聯(lián)合丙酸氟替卡松鼻噴霧劑治療過敏性鼻炎的臨床療效。方法 選取2018年7月-2019年7月在連云港市第一人民醫(yī)院進行治療的92例過敏性鼻炎患者，根據(jù)用藥的差別分為對照組（46例）和治療組（46例）。對照組給予丙酸氟替卡松鼻噴霧劑，1次/d，每鼻孔2噴，個別患者可以2次/d，每鼻孔2噴，癥狀控制后維持每個鼻孔1噴，1次/d；治療組在對照組基礎(chǔ)上口服千柏鼻炎片，4片/次，3次/d。兩組均治療8周。觀察兩組的臨床療效，比較兩組治療前后臨床積分、血清學(xué)指標(biāo)的變化情況。結(jié)果 治療后，對照組和治療組的總有效率分別是80.43%、95.65%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。經(jīng)治療，兩組在噴嚏、鼻塞、流涕、鼻癢等癥狀積分均顯著降低（P<0.05），且以治療組顯著（P<0.05）。經(jīng)治療，兩組患者血清白細胞介素-4（IL-4）、測白細胞介素-6（IL-6）、測白細胞介素-17（IL-17）、細胞間黏附分子-1（ICAM-1）、嗜酸性細胞陽離子蛋白（ECP）水平均顯著降低（P<0.05），且以治療組顯著（P<0.05）。結(jié)論 千柏鼻炎片聯(lián)合丙酸氟替卡松鼻噴霧劑治療過敏性鼻炎具有較好的臨床效果，可有效改善患者臨床癥狀，降低機體炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Qianbai Biyan Tablets combined with fluticasone propionate in treatment of allergic rhinitis. Methods 92 Patients with allergic rhinitis admitted to the First People's Hospital of Lianyungang from July 2018 to July 2019 were divided into control group (n=46) and treatment group (n=46) according to the different medication. The control group was given Fluticasone Propionate Nasal Spray, once daily, two per nostril, individual patients can spray twice daily, two per nostril. After symptom control, maintain 1 spray per nostril, once daily. The treatment group was po administered with Qianbai Biyan Tablets on the basis of the control group, 4 tablets/time, three times daily. All patients were treated for 8 weeks. The clinical efficacy of the two groups was observed, and the changes of clinical scores and serological indexes before and after treatment were compared. Results After treatment, the effective rate of the control group was 80.43%, significantly lower than that of the treatment group (95.65%, P<0.05). After treatment, the scores of symptoms such as sneezing, nasal obstruction, runny nose and nasal itching in the two groups decreased, and the treatment group was the most significant (P<0.05). After treatment, the serum levels of IL-4, IL-6, IL-17, ICAM-1 and ECP in the two groups were all decreased, especially in the treatment group (P<0.05). Conclusion Qianbai Biyan Tablets combined with fluticasone propionate has good clinical effect in treatment of allergic rhinitis, and can effectively improve the clinical symptoms of patients, and also can reduce the body inflammatory response, which has good clinical application value.

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