目的 探討安胃瘍膠囊聯(lián)合替普瑞酮膠囊治療胃潰瘍的臨床療效。方法 選取2017年6月-2019年6月在駐馬店市中醫(yī)院治療的102例胃潰瘍患者，根據(jù)用藥差別分為對照組（51例）和治療組（51例）。對照組患者口服替普瑞酮膠囊，50 mg/次，3次/d；治療組在對照組基礎(chǔ)上口服安胃瘍膠囊，0.4 g/次，4次/d。兩組患者均經(jīng)4周治療。觀察兩組患者臨床療效，比較兩組患者癥候積分、GQOL-74量表評分、幽門螺桿菌根除率、潰瘍愈合率、胃動素（MTL）、胃泌素（GAS）、生長抑素（SS）和降鈣素基因相關(guān)肽水平（CGRP）水平，以及血清血管內(nèi)皮生長因子（VEGF）、白細胞介素-8（IL-8）、IL-17、高遷移率族蛋白B1（HMGB1）、基質(zhì)金屬蛋白酶-9（MMP-9）和前列腺素E2（PGE2）水平。結(jié)果 治療后，對照組和治療組臨床有效率分別為80.39%、98.04%，兩組比較差異有統(tǒng)計學意義（P<0.05）。經(jīng)治療，兩組患者癥候積分和GQOL-74評分均明顯下降（P<0.05），且治療組比對照組降低更明顯（P<0.05）。經(jīng)治療，治療組幽門螺桿菌根除率和潰瘍愈合率均顯著高于對照組（P<0.05）。經(jīng)治療，兩組患者MTL、GAS、IL-8、IL-17、HMGB1、MMP-9表達均明顯下降（P<0.05），CGRP、SS、VEGF和PGE2水平均明顯升高（P<0.05），且治療后治療組這些指標水平明顯好于對照組（P<0.05）。結(jié)論 安胃瘍膠囊聯(lián)合替普瑞酮膠囊治療胃潰瘍可顯著促進患者臨床癥狀改善，改善患者生活質(zhì)量、胃腸激素水平，促進潰瘍愈合。

Objective To explore the clinical efficacy of Anweiyang Capsules combined with teprenone in treatment of gastric ulcer. Methods Patients (102 cases) with gastric ulcer in Zhumadian TCM Hospital from June 2017 to June 2019 were divided into control (51 cases) and treatment (51 cases) groups based on different treatments. Patients in the control group were po administered with Teprenone Capsules, 50 mg/time, three times daily. Patients in the treatment group were po administered with Anweiyang Capsules on the basis of the control group, 0.4 g/time, four times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the symptom scores, the GQOL-74 scale scores, the eradication rate of Hp, ulcer healing rate, and the level of MTL, GAS, SS, CGRP, VEGF, IL-8, IL-17, HMGB1, MMP-9 and PGE2 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 80.39% and 98.04%, respectively, and there were differences between two groups (P < 0.05). After treatment, the symptom scores and GQOL-74 scale scores in two groups were significantly decreased (P < 0.05), and these scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the eradication rate of Hp and ulcer healing rate in the treatment group was significantly higher than that in the control group (P < 0.05). After treatment, the levels of MTL, GAS, IL-8, IL-17, HMGB1, and MMP-9 in two groups were significantly decreased (P < 0.05), but the levels of CGRP, SS, VEGF, and PGE2 in two groups were significantly increased (P < 0.05), and these indexes in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Anweiyang Capsules combined with teprenone in treatment of gastric ulcer can significantly improve the clinical symptoms, improve the quality of life and gastrointestinal hormone level, and promote ulcer healing.

R975