目的 探討降脂通脈膠囊聯(lián)合藻酸雙酯鈉片治療高脂血癥的臨床療效。方法 選擇2018年3月-2019年3月在陜西省榮譽(yù)軍人康復(fù)醫(yī)院治療的高脂血癥患者86例，根據(jù)用藥的差別分為對(duì)照組（43例）和治療組（43例）。對(duì)照組口服藻酸雙酯鈉片，50 mg/次，3次/d；治療組在對(duì)照組基礎(chǔ)上口服降脂通脈膠囊，2.0 g/次，3次/d。兩組患者經(jīng)4周治療。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者高密度脂蛋白膽固醇（HDL-C）、低密度脂蛋白膽固醇（LDL-C）、三酰甘油（TG）、膽固醇（TC）、嗜酸性粒細(xì)胞陽(yáng)離子蛋白（ECP）、攝食抑制因子-1（NSF-1）、硫氧還蛋白相互作用蛋白（TXNIP）、腫瘤壞死因子-α（TFN-α）、白細(xì)胞介素-1β（IL-1β）、脂聯(lián)素（ADP）、超氧化物歧化酶（SOD）、丙二醛（MDA）和谷胱甘肽過(guò)氧化物酶（GSH-Px）水平。結(jié)果 治療后，對(duì)照組臨床有效率為81.40%，顯著低于治療組的97.67%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者TC、TG、LDL-C、ECP、IL-1β、TFN-α、TXNIP、NSF-1和MDA水平均顯著降低（P<0.05），而HDL-C、ADP、SOD和GSH-Px水平均顯著升高（P<0.05），且治療組患者這些指標(biāo)明顯好于對(duì)照組（P<0.05）。結(jié)論 降脂通脈膠囊聯(lián)合藻酸雙酯鈉片治療高脂血癥可有效降低血脂指標(biāo)，促進(jìn)機(jī)體細(xì)胞因子和氧化應(yīng)激指標(biāo)的改善，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Jiangzhi Tongmai Capsules combined with sodium alginate diester in treatment of hyperlipidemia. Methods Patients (86 cases) with hyperlipidemia in Shaanxi Rongjun Rehabilitation Hospital from March 2018 to March 2019 were divided into control (43 cases) and treatment (43 cases) groups based on different treatments. Patients in the control group were po administered with Sodium Alginate Diester Tablets, 50 mg/time, three times daily. Patients in the treatment group were po administered with Jiangzhi Tongmai Capsules on the basis of the control group, 2 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the levels of TC, TG, LDL-C, HDL-C, ECP, IL-1β, TFN-α, TXNIP, NSF-1, SOD, GSH-Px and MDA in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.40%, which was significantly lower than 97.67% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the levels of TC, TG, LDL-C, ECP, IL-1β, TFN-α, TXNIP, NSF-1 and MDA in two groups were significantly decreased (P < 0.05), but the HDL-C, ADP, SOD and GSH-Px levels were significantly increased (P < 0.05), and these indexes in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Jiangzhi Tongmai Capsules combined with sodium alginate diester in treatment of hyperlipidemia can effectively reduce blood lipid level, promote the improvement of cytokines and oxidative stress, which has a certain clinical application value.

R972