目的 探討鹽酸氨基葡萄糖膠囊聯(lián)合復(fù)方骨肽注射液治療膝骨關(guān)節(jié)炎的臨床效果。方法 選取2016年1月-2018年1月湘西土家族苗族自治州人民醫(yī)院收治的114例膝骨關(guān)節(jié)炎患者，隨機(jī)分為對照組和治療組，每組各57例。對照組靜脈滴注復(fù)方骨肽注射液，10 mL用250 mL等滲鹽水充分稀釋后給藥，1次/d。治療組在對照組治療基礎(chǔ)上口服鹽酸氨基葡萄糖膠囊，2粒/次，3次/d。兩組均連續(xù)治療4周。觀察兩組的臨床療效，比較兩組治療前后西安大略和麥克馬斯特大學(xué)（WOMAC）量表評分、膝關(guān)節(jié)高頻超聲參數(shù)、白介素（IL）-1β、基質(zhì)金屬蛋白酶（MMP）-3、軟骨寡聚基質(zhì)蛋白（COMP）、蛋白聚糖（PG）水平的變化情況。結(jié)果 治療后，對照組和治療組的總有效率分別為77.2%、91.2%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組疼痛評分、僵硬評分、關(guān)節(jié)功能評分及總分較治療前均顯著下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05），治療后治療組疼痛評分、僵硬評分、關(guān)節(jié)功能評分及總分均顯著低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組軟骨厚度均顯著增加，滑膜厚度、IL-1β、MMP-3、COMP、PG均顯著減少，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組軟骨厚度顯著高于對照組，滑膜厚度、IL-1β、MMP-3、COMP、PG顯著低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 鹽酸氨基葡萄糖膠囊聯(lián)合復(fù)方骨肽注射液治療膝骨關(guān)節(jié)炎具有較好的臨床療效，可有效緩解患者癥狀，減輕炎性損傷，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Glucosamine Hydrochloride Capsules combined with Compound Ossotide Injection intreatment of knee osteoarthritis. Methods Patients (114 cases) with knee osteoarthritis in People's Hospital of Xiangxi Tujia and Miao Autonomous Prefecture from January 2016 to January 2018 were randomly divided into control (57 cases) and treatment (57 cases) groups. Patients in the control group were iv administered with Compound Ossotide Injection, 10 mL was fully diluted with 250 mL isobaric saline, once daily. Patients in the treatment group were po administered with Glucosamine Hydrochloride Capsules, 2 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the changes of WOMAC score, high frequency ultrasound parameters of knee joints, IL-1β, MMP-3, COMP, and PG in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group were 77.2% and 91.2%, and there were differences between two groups (P<0.05). After treatment, the pain score, stiffness score, joint function score and total score in two groups were significantly decreased, and there were differences in the same group (P<0.05).After treatment, the pain score, stiffness score, joint function score and total score in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, cartilage thickness was increased significantly in both groups, but synovial thickness, IL-1β, MMP-3, COMP, and PG were significantly decreased, and there were differences in the same group (P<0.05). After treatment, cartilage thickness in the treatment group was higher than that in the control group, but synovial thickness, IL-1β, MMP-3, COMP, and PG were lower than those in the control group, and there were differences between two groups (P<0.05). Conclusion Glucosamine Hydrochloride Capsules combined with Compound Ossotide Injection has significant clinical effect in treatment of knee osteoarthritis, and can effectively alleviate symptoms, and reduce inflammatory injury, which has a certain clinical application value.