Objective To investigate the regularities and characteristics of adverse reactions caused by cefodizime, and to provide a reference for clinical rational drug use. Methods PubMed databases, Chinese Academic Journal (online), Wangfang Database, Chinese Science, and Technology Journal Full-text Database (VIP) were retrieved from building database to February 2018, and the documents of ADR induced by cefodizime were analyzed and discussed. Results A total of 24 literatures with 33 patients were retrieved. The ages of patients were mainly 0-18 years old and above 60 years old. The main method of administration was intravenous drip. The primary disease was mainly respiratory infection. The most cases occured in the medication in 30 min, accounting for 42.42%. ADR induced by cefodizime mainly occured in systemic damage, digestive system hurt, skin and accessory damage, cardiovascular system damage, and nervous system damage, in which systemic damage took the most ratios. And the main clinical manifestation were anaphylaxis and allergic shock. Conclusion Importance should be attached to the danger of ADR induced by cefodizime and pharmaceutical care should be strengthened, to avoid or reduce the incidence of ADR to ensure medication safety.