目的 探討滋腎育胎丸聯(lián)合烯丙雌醇片治療先兆流產(chǎn)的有效性與安全性。方法 選取鄭州大學(xué)附屬洛陽中心醫(yī)院2015年5月-2017年5月收治的先兆流產(chǎn)患者141例，隨機(jī)分成治療組（71例）和對(duì)照組（70例）。對(duì)照組患者口服烯丙雌醇片，2片/次，1次/d；治療組患者在對(duì)照組基礎(chǔ)上口服滋腎育胎丸，5 g/次，3次/d。兩組患者均經(jīng)連續(xù)治療7 d。評(píng)價(jià)兩組患者保胎成功率，同時(shí)比較治療前后兩組患者止血時(shí)間、腰腹疼痛緩解時(shí)間、陰道流血量、孕酮、子宮動(dòng)脈血流阻力指數(shù)（RI）和搏動(dòng)指數(shù)（PI）水平及不良反應(yīng)情況。結(jié)果 治療后，對(duì)照組保胎成功率為75.71%，顯著低于治療組的90.14%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組患者止血時(shí)間和腰腹疼痛緩解時(shí)間顯著短于對(duì)照組，治療組陰道流血量顯著小于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者孕酮水平顯著升高，RI和PI水平顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。且治療后治療組患者孕酮、RI和PI水平明顯優(yōu)于對(duì)照組（P<0.05）。治療期間，對(duì)照組患者不良反應(yīng)為15.71%，顯著高于治療組的4.23%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 滋腎育胎丸聯(lián)合烯丙雌醇片治療先兆流產(chǎn)保胎率高，不良反應(yīng)發(fā)生率低，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the effectiveness and safety of Zishen Yutai Pills combined with allylestrenol in treatment of threatened abortion. Methods Patients (141 cases) with threatened abortion in Luoyang Central Hospital Affiliated to Zhengzhou University from May 2015 to May 2017 were randomly divided into control (70 cases) and treatment (71 cases) groups. Patients in the control group were po administered with Allylestrenol Tablets, 2 tablets/time, once daily. Patients in the treatment group were po administered with Zishen Yutai Pills on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the success rate of tocolysis was evaluated, the hemostasis time, remission time of lumbar abdominal pain, vaginal bleeding, progesterone, RI and PI levels, and the adverse reactions in two groups before and after treatment were compared. Results After treatment, the success rate of tocolysis in the control group was 75.71%, which was significantly lower than 90.14% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the hemostasis time and remission time of lumbar abdominal pain in the treatment group was significantly shorter than that in the control group, and the vaginal bleeding volume was significantly smaller than that in the control group, with significant difference between two groups (P<0.05). After treatment, the progesterone level in two groups was significantly increased, but RI and PI level was significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the progesterone, RI, and PI level in the treatment group after treatment were significantly better than those in the control group (P<0.05). During the treatment, the adverse reactions rate in the control group was 15.71%, which was significantly higher than 4.23% in the treatment group, with significant difference between two groups (P<0.05). Conclusion Zishen Yutai Pills combined with allylestrenol has higher tocolysis rate in treatment of threatened abortion with lower adverse reactions incidence, which has a certain clinical application value.