目的 研究固腸止瀉丸聯(lián)合柳氮磺吡啶腸溶片治療潰瘍性結(jié)腸炎的臨床療效。方法 選取2016年2月-2017年2月三二〇一醫(yī)院收治的潰瘍性結(jié)腸炎患者86例為研究對象，采用隨機(jī)數(shù)字表法將患者分為對照組和治療組，每組各43例。對照組飯前口服柳氮磺吡啶腸溶片，1 g/次，3次/d。治療組在對照組基礎(chǔ)上口服固腸止瀉丸，5 g/次，3次/d。兩組患者均連續(xù)治療6周。觀察兩組的癥狀療效和內(nèi)鏡療效，比較兩組的黏膜愈合情況和時(shí)間以及實(shí)驗(yàn)室指標(biāo)。結(jié)果 治療后，對照組和治療組的癥狀療效總有效率分別為79.07%、95.35%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，對照組和治療組的內(nèi)鏡療效總有效率分別為81.40%、95.35%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組Baron評分顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組Baron內(nèi)鏡評分明顯低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組黏膜愈合時(shí)間顯著短于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組ESR、PLT和D-二聚體水平均顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組實(shí)驗(yàn)室指標(biāo)明顯低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 固腸止瀉丸聯(lián)合柳氮磺吡啶腸溶片治療潰瘍性結(jié)腸炎具有較好的臨床療效，可改善臨床癥狀，降低炎癥水平，促進(jìn)黏膜愈合，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To study the clinical effect of Guchang Zhixie Pills combined with Sulfasalazine Enteric-coated Tablets in treatment of ulcerative colitis. Methods Patients (86 cases) with ulcerative colitis in San Er Ling Yi Hospital, from February 2016 to February 2017 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Sulfasalazine Enteric-coated Tablets, 1 g/time, three times daily. Patients in the treatment group were po administered with Guchang Zhixie Pills on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated for 6 weeks. After treatment, clinical efficacies of symptom and endoscope were evaluated, and mucous healing condition, mucous healing time, and laboratory indexes in two groups were compared. Results After treatment, the clinical efficacies of symptom in the control and treatment groups were 79.07% and 95.35%, respectively, and there was difference between two groups (P<0.05). After treatment, the clinical efficacies of endoscope in the control and treatment groups were 81.40% and 95.35%, respectively, and there was difference between two groups (P<0.05). After treatment, the Baron score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the Baron score in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P<0.05). After treatment, the mucous healing time in the treatment group was significantly shorter than that in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of ESR, PLT, and D-dipolymer in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Guchang Zhixie Pills combined with Sulfasalazine Enteric-coated Tablets has clinical curative effect in treatment of ulcerative colitis, can improve clinical symptoms, decrease inflammation level, and promote the healing of mucous membrane, which has a certain clinical application value.