目的 探討注射用炎琥寧聯(lián)合吸入用乙酰半胱氨酸溶液治療肺部感染的臨床療效。方法 選擇2016年1月-2017年1月西寧市第三人民醫(yī)院收治的肺部感染患者153例為研究對(duì)象，隨機(jī)分為對(duì)照組（76例）和治療組（77例）。對(duì)照組霧化吸入吸入用乙酰半胱氨酸溶液，3 mL/次，2次/d。治療組在對(duì)照組治療基礎(chǔ)上靜脈滴注注射用炎琥寧，160 mg加入到5%葡萄糖注射液250 mL中，1次/d。兩組患者均連續(xù)治療7 d。觀察兩組的臨床療效，比較兩組的臨床肺部感染評(píng)分（CPIS）、白細(xì)胞計(jì)數(shù)、臨床癥狀、肺部X片恢復(fù)時(shí)間和炎癥因子水平。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為85.53%、97.40%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組CPIS和白細(xì)胞計(jì)數(shù)均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組體溫恢復(fù)時(shí)間、咳痰消失時(shí)間、肺部X片恢復(fù)正常時(shí)間短于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組超敏C反應(yīng)蛋白（hs-CRP）和降鈣素（PCT）水平均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組炎癥因子水平明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 注射用炎琥寧聯(lián)合吸入用乙酰半胱氨酸溶液治療肺部感染具有較好的臨床療效，可改善臨床癥狀，降低炎癥反應(yīng)，安全性好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Potassium Sodium Dehydroandrographolide Succinate for injection combined with Acetylcysteine Solution for inhalation in treatment of pulmonary infection. Methods Patients (153 cases) with pulmonary infection in the Third People's Hospital of Xining from January 2016 to January 2017 were randomly divided into the control group (76 cases) and the treatment groups (77 cases). Patients in the control group were atomization inhalation administered with Acetylcysteine Solution for inhalation, 3 mL/time, twice daily. Patients in the treatment group were iv administered with Potassium Sodium Dehydroandrographolide Succinate for injection on the basis of the control group, 160 mg added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and CPIS, white blood cell count, the recovery time of clinical symptoms, lung X-ray, and the levels of inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.53% and 97.40%, respectively, and there was difference between two groups (P<0.05). After treatment, CPIS and white blood cell count in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the recovery time of body temperature, the time of expectoration disappeared, and the recovery time of lung X-ray in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of hs-CRP and PCT in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the levels of inflammatory factor indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Potassium Sodium Dehydroandrographolide Succinate for injection combined with Acetylcysteine Solution for inhalation has clinical curative effect in treatment of pulmonary infection, can improve clinical symptoms, and decrease inflammatory reactions, with good safety, which has a certain clinical application value.