目的 評價阿加曲班聯(lián)合阿司匹林治療后循環(huán)進展性腦梗死急性期的臨床療效。方法 選取2017年1月-2017年9月大理大學附屬醫(yī)院收治的后循環(huán)進展性腦梗死急性期患者80例，隨機分為對照組（40例）和治療組（40例）。對照組口服阿司匹林腸溶片，1片/次，每晚一次；治療組在對照組的基礎上靜脈泵注阿加曲班注射液，60 mg加入生理鹽水25 mL，持續(xù)48 h，治療2 d后10 mg加入25 mL生理鹽水中，2次/d。兩組均治療14 d。觀察兩組患者臨床療效，比較治療前后兩組患者國立衛(wèi)生研究院卒中量表（NIHSS）和BI評分。結果 治療后，對照組和治療組臨床有效率分別為67.5%和87.5%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療7、14 d后，兩組患者NIHSS評分明顯降低，BI評分明顯升高，同組治療前后比較差異具有統(tǒng)計學意義（P<0.05）；且治療7、14 d后，治療組NIHSS評分和BI評分明顯優(yōu)于同期對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 阿加曲班聯(lián)合阿司匹林治療急性腦梗死后循環(huán)進展性卒中急性期療效顯著，可促進神經(jīng)功能恢復，有利于改善日?；顒幽芰?。

Objective To evaluate the clinical efficacy of argatrob combined with aspirin in treatment of progressive infarcts in posterior circulation. Methods Patients (80 cases) with progressive infarcts in posterior circulation in the First Affiliated Hospital of Dali University from January 2017 to September 2017 were randomly divided into control (40 cases) and treatment (40 cases) groups. Patients in the control group were po administered with Aspirin Enteric-coated Tablets, 1 tablet/time, once every night. Patients in the treatment group were intravenous pumping administered with Argatroban Injection on the basis of the control group, 60 mg added into normal saline 25 mL, maintained for 48 h, and 10 mg added into normal saline 25 mL after treatment for 2 d, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, the NIHSS and BI scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 67.5% and 87.5% respectively, and there were differences between two groups (P<0.05). After treatment for 7 d and 14 d, the NIHSS scores in two groups were significantly decreased, but BI scores were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the NIHSS and BI scores in the treatment group after treatment for 7 d and 14 d were significantly better than those in the control group in the same period, with significant difference between two groups (P<0.05). Conclusion Argatroban combined with aspirin in treatment of progressive infarcts in posterior circulation has an accurate curative effect, which can promote the recovery of nerve function and improve the ability of daily activities.