目的 了解南京地區(qū)抗侵襲性真菌感染藥物的使用情況和變化趨勢，為臨床合理使用藥物提供參考。方法 采用回顧性分析方法對南京地區(qū)2014—2016年38家醫(yī)院抗侵襲性真菌感染藥物的用藥金額、用藥頻度（DDDs）、限定日費用（DDC）及B/A進行統(tǒng)計分析。結果 2014—2016年，南京地區(qū)抗侵襲性真菌感染藥物的用藥金額逐年上升，復合年均增長率（CAGR）為11.84%，藥物選擇主要集中在三唑類；其中伏立康唑注射劑的銷售金額、伊曲康唑口服制劑的DDDs、卡泊芬凈注射劑的DDC連續(xù)3年居首位；另外抗真菌藥物的使用出現(xiàn)新的變化；三級醫(yī)院抗真菌藥的用藥金額占比最高；南京地區(qū)抗真菌藥的選擇以進口藥和國產(chǎn)藥為主。結論 南京地區(qū)抗侵襲性真菌感染藥物的使用量逐年攀升，藥物消費市場結構較為穩(wěn)定；加強管理，促進抗侵襲性真菌感染藥物合理使用。

Objective To evaluate the utilization and trend of anti-invasive fungal infection drugs in Nanjing area, and to provide a reference for clinical rational use of drugs. Methods Consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and sequence ratio (B/A) of anti-invasive fungal infection dugs in 38 hospitals of Nanjing area from 2014 to 2016 were retrospectively analyzed. Results From 2014 to 2016, consumption sum of anti-invasive fungal infection drugs in Nanjing area increased year by year with a CAGR of 11.84%. The choice of drugs mainly focused on triazoles. Consumption sum of Voriconazole Injection, DDDs of Itraconazole oral preparations, DDC of Caspofungin Injection took the first place for three years in succession. Additionally, new changes had taken place in the use of anti-invasive fungal infection drugs. Consumption sum accounted for the highest proportion in tertiary hospitals, and antifungal agents in Nanjing area was mainly imported drugs and domestic drugs. Conclusion The use of anti-invasive fungal infection drugs in Nanjing increases year by year, and the structure of drug consumption market is relatively stable. Management was strengthened to promote the rational use of anti-invasive fungal infection drugs.

常州四藥醫(yī)院藥學科研基金資助項目（2017YX003）