目的 探討葛根素注射液聯(lián)合鹽酸多奈哌齊片治療帕金森病的臨床療效。方法 選取2016年2月—2017年12月南陽市中心醫(yī)院收治的帕金森病患者98例為研究對(duì)象，所有患者隨機(jī)分為對(duì)照組和治療組，每組各49例。對(duì)照組患者睡前口服鹽酸多奈哌齊片，1片/次，1次/d，維持1個(gè)月，然后根據(jù)治療效果增加劑量至2片/次，1片/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注葛根素注射液，400 mg加入到5%葡萄糖溶液500 mL中，1次/d。15 d為1個(gè)療程，兩組患者連續(xù)治療3個(gè)療程。觀察兩組的臨床療效，比較兩組的改良Webster癥狀評(píng)分。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為79.59%、91.83%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者改良Webster癥狀評(píng)分均顯著下降，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者改良Webster癥狀評(píng)分顯著低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 葛根素注射液聯(lián)合鹽酸多奈哌齊片治療帕金森病具有較好的臨床療效，可改善臨床癥狀，安全性較好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Puerarin Injection combined with Donepezil Hydrochloride Tablets in treatment of Parkinson's disease. Methods Patients (98 cases) with Parkinson's disease in Nanyang City Central Hospital from February 2016 to December 2017 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were po administered with Donepezil Hydrochloride Tablets at bedtime, 1 tablet/time, once daily, treated for 1 month, then dosage changed to 2 tablets/time, once daily. Patients in the treatment group were iv administered with Puerarin Injection on the basis of the control group, 400 g added into 5% glucose solution 500 mL, once daily. One course was 15 d, and patients in two groups were treated for 3 courses. After treatment, the clinical efficacies were evaluated, and improved Webster symptom scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.59% and 91.83%, respectively, and there was difference between two groups (P < 0.05). After treatment, improved Webster symptom scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And improved Webster symptom scores in the treatment group was significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Puerarin Injection combined with Donepezil Hydrochloride Tablets has clinical curative effect in treatment of Parkinson's disease, can improve clinical symptoms, with good safety, which has a certain clinical application value.