目的 探討氯雷他定聯(lián)合法莫替丁治療嗜酸性粒細(xì)胞性胃腸炎的臨床療效。方法 選取2016年12月—2017年12月首都醫(yī)科大學(xué)附屬北京世紀(jì)壇醫(yī)院收治的嗜酸性粒細(xì)胞性胃腸炎的患者42例，隨機(jī)分為對(duì)照組和治療組，每組各21例。對(duì)照組餐前口服法莫替丁片，20 mg/次，2次/d。治療組在對(duì)照組治療基礎(chǔ)上口服氯雷他定片，10 mg/次，1次/d。兩組均連續(xù)治療8周。觀察兩組的臨床療效，比較兩組治療前后血嗜酸粒細(xì)胞計(jì)數(shù)、組織嗜酸粒細(xì)胞計(jì)數(shù)、IgE水平的變化情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為80.95%和95.23%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血嗜酸粒細(xì)胞計(jì)數(shù)、組織嗜酸粒細(xì)胞計(jì)數(shù)、IgE水平均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組血嗜酸粒細(xì)胞計(jì)數(shù)、組織嗜酸粒細(xì)胞計(jì)數(shù)、IgE水平顯著低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 氯雷他定聯(lián)合法莫替丁治療嗜酸性粒細(xì)胞性胃腸炎具有較好的臨床療效，降低患者外周血及組織中嗜酸性粒細(xì)胞水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of loratadine combined with famotidine in treatment of eosinophilic gastroenteritis. Methods Patients (42 cases) with eosinophilic gastroenteritis in Beijing Shijitan Hospital Affiliated Capital Medical University from December 2016 to December 2017 were randomly divided into control (21 cases) and treatment (21 cases) groups. Patients in the control group were po administered with Famotidine Tablets before meal, 20 mg/time, twice daily. Patients in the treatment group were po administered with Loratadine Tablets on the basis of the control group, 10 mg/time, once daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the blood eosinophil count, tissue eosinophil count and IgE level in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.95% and 95.23%, and there were differences between two groups (P < 0.05). After treatment, blood eosinophil count, tissue eosinophil count and IgE level in two groups were significantly decreased, and there were differences in the same group (P < 0.05). After treatment, blood eosinophil count, tissue eosinophil count and IgE level in the treatment group were lower than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Loratadine combined with famotidine has significant clinical effect in treatment of eosinophilic gastroenteritis, and can reduce the level of eosinophils in peripheral blood and tissues, which has a certain clinical application value.