多發(fā)性骨髓瘤SET結(jié)構(gòu)域蛋白（MMSET）作為NSD組蛋白甲基轉(zhuǎn)移酶家族的成員之一，在人類胚胎發(fā)育等生理過程中發(fā)揮著重要的作用。近年來大量研究表明，MMSET在多發(fā)性骨髓瘤、前列腺癌、乳腺癌、卵巢癌、胃癌等各種惡性腫瘤中過表達(dá)，抑制MMSET的表達(dá)能夠通過抑制腫瘤增殖、抑制腫瘤侵襲轉(zhuǎn)移、抑制腫瘤DNA損傷修復(fù)、抑制磷酸戊糖途徑及逆轉(zhuǎn)腫瘤耐藥等來抑制腫瘤的發(fā)展。因此發(fā)展MMSET相關(guān)靶向藥物有望成為腫瘤治療的新方向。通過查閱國內(nèi)外相關(guān)文獻(xiàn)，總結(jié)MMSET相關(guān)靶向藥物可能的抗腫瘤機(jī)制及MMSET相關(guān)靶向藥物的發(fā)展現(xiàn)狀。

MMSET plays an important role in human embryonic development and other physiological processes as a member of NSD histone methyltransferase family. In recent years, a large number of evidence has shown that MMSET is frequently hyperactivated in multiple myeloma, prostate cancer, breast cancer, ovarian cancer, gastric cancer, and other malignant tumors. The expression of MMSET can be suppressed by inhibiting tumor proliferation, invasion and metastasis, DNA damage repair, pentose phosphate pathway, and reversing tumor resistance to inhibit the development of tumor. In this paper, the possible anti-tumor mechanisms and development status of MMSET related targeted drugs are summarized by referring to relevant literatures.

遼寧省卵巢癌惡性腫瘤病例信息平臺的建立及診治技術(shù)規(guī)范化推廣項(xiàng)目（LNCCC-A01-2015）；沈陽市科技計(jì)劃項(xiàng)目（17-230-9-10）