目的 觀察百令膠囊聯(lián)合氯沙坦鉀治療慢性腎小球腎炎的臨床療效。方法 選取長(zhǎng)江航運(yùn)總醫(yī)院于2015年10月-2017年5月收治的112例慢性腎小球腎炎患者，隨機(jī)分為對(duì)照組和治療組，每組各56例。對(duì)照組口服氯沙坦鉀片，50 mg/次，1次/d。治療組在對(duì)照組的基礎(chǔ)上口服百令膠囊，5粒/次，3次/d。兩組患者持續(xù)治療3個(gè)月。比較兩組治療前后的臨床療效，觀察兩組治療前后腎功能、營(yíng)養(yǎng)狀態(tài)和血清Lkn-1和VEGF水平的變化情況。結(jié)果 治療后，對(duì)照組和治療組的臨床總有效率分別為76.79%和92.86%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組Scr、BUN、24 h尿蛋白定量水平均較治療前顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05），且治療后治療組Scr、BUN、24 h尿蛋白定量水平均顯著低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組患者血清總蛋白和白蛋白含量均較治療前顯著升高，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05），且治療組血清總蛋白和白蛋白含量均顯著高于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組血清Lkn-1和VEGF水平均較治療前顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05），且治療組血清Lkn-1和VEGF水平均顯著低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 百令膠囊聯(lián)合氯沙坦鉀治療慢性腎小球腎炎療效顯著，同時(shí)能明顯改善患者營(yíng)養(yǎng)狀態(tài)，降低其血清Lkn-1和VEGF水平。

Objective To observe the clinical effect of Bailing Capsule combined with losartan potassium in treatment of chronic glomerulonephritis. Methods Patients (112 cases) with chronic glomerulonephritis in Yangtze River Shipping General Hospital from October 2015 to May 2017 were randomly divided into control and treatment groups. Each group had 56 cases. Patients in the control group were po administered with Losartan Potassium Tablets, 50 mg/time, once daily. Patients in the treatment group were po administered with Bailing Capsule on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy were evaluated, renal function, state of nutrition, and Lkn-1 and VEGF levels in serum in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the control and treatment groups were 76.79% and 92.86%, respectively, and there were differences between two groups (P < 0.05). Scr, BUN, and 24 h urine protein quantity levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Total protein and albumin levels in serum in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And these levels were higher than those in the control group, with significant difference between two groups (P < 0.05). Lkn-1 and VEGF in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And Lkn-1 and VEGF levels were significantly lower than those in the control group, with significant difference between two groups (P < 0.05).Conclusion Bailing Capsule combined with losartan potassium has good effect in treatment of chronic glomerulonephritis, and can significantly improve the nutritional status of patients and reduce the level of serum Lkn-1 and VEGF.