目的 探討曲安奈德注射液聯(lián)合巴曲酶注射液治療突發(fā)性耳聾的臨床療效。方法 選取2016年3月-2017年3月南陽市中心醫(yī)院耳鼻喉科收治的突發(fā)性耳聾患者125例為研究對象，所有患者在隨機分組的原則下分為對照組（62例）和治療組（63例）。對照組均靜脈滴注巴曲酶注射液，首次10 BU（而后5 BU）加入到生理鹽水250 mL中，1次/2 d。治療組患者在對照組基礎上鼓室內(nèi)注射曲安奈德注射液，40 mg/次，1次/2 d。兩組患者均連續(xù)治療10 d。觀察兩組的臨床療效，比較兩組的臨床癥狀、平均聽閾提高值、纖維蛋白原（FIB）、縫隙連接蛋白原26（connexin 26）、縫隙連接蛋白原30（connexin 30）水平。結果 治療后，對照組和治療組的總有效率分別為83.87%、96.83%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，治療組聽力恢復時間、耳鳴消失時間、眩暈消失時間明顯短于對照組，且治療組平均聽閾提高值明顯高于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組FIB水平顯著降低，connexin 26、connexin 30水平顯著升高，同組治療前后比較差異具有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 曲安奈德注射液聯(lián)合巴曲酶注射液治療突發(fā)性耳聾具有較好的臨床療效，可改善臨床癥狀，升高平均聽閾值，調(diào)節(jié)FIB、connexin 26、connexin 30水平，具有一定的臨床推廣應用價值。

Objective To explore the clinical effect of Triamcinolone Acetonide Injection combined with Batroxobin Injection in treatment of sudden deafness. Methods Patients (125 cases) with sudden deafness in Department of Ear-Nose-Throat of Nangyang City Central Hospital from March 2016 to March 2017 were randomly divided into the control group (62 cases) and the treatment group (63 cases). Patients in the control group were iv administered with Batroxobin Injection, first dosage 10 BU (then 5 BU) added into normal saline 250 mL, once every two days. Patients in the treatment group were intratincular injection administered with Triamcinolone Acetonide Injection on the basis of the control group, 40 mg/time, once every two days. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and clinical symptoms, average hearing threshold increased value, and the levels of FIB, connexin 26, and connexin 30 in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.87% and 96.83%, respectively, and there was difference between two groups (P < 0.05). After treatment, hearing recovery time, tinnitus disappearance time, and vertigo disappearance time in the treatment group were shorter than those in the control group, and the average hearing threshold increased values in the treatment group was higher than those in the control group, and there was difference between two groups (P < 0.05). After treatment, the levels of FIB in two groups were significantly decreased, but the levels of connexin 26 and connexin 30 in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Triamcinolone Acetonide Injection combined with Batroxobin Injection has clinical curative effect in treatment of sudden deafness, can improve clinical symptom, increase average hearing threshold, and regulate the levels of FIB, connexin 26, and connexin 30, which has a certain clinical application value.