目的 觀察參芎葡萄糖注射液聯合腦苷肌肽治療新生兒缺氧缺血性腦病的臨床療效。方法 收集2015年1月—2017年4月鄂州市中心醫(yī)院新生兒科收治的新生兒缺氧缺血性腦病患兒67例，隨機分為對照組（30例）和治療組（37例），對照組患兒靜脈滴注腦苷肌肽注射液，2 mL加入到0.9%氯化鈉注射液50 mL中，1次/d。治療組患兒在對照組的基礎上靜脈滴注參芎葡萄糖注射液，50 mL/次，1次/d。兩組患兒均治療14 d。觀察兩組患者臨床療效，比較治療前后兩組患者臨床體征恢復情況、血清一氧化氮（NO）、內皮素-1（ET-1）、脂聯素（APN）和胰島素樣生長因子-1（IGF-1）、神經行為評分（NBNA）和預后情況。結果 治療后，對照組和治療組臨床總有效率分別為73.33%、83.78%，兩組比較差異具有統(tǒng)計學意義（P < 0.05）。治療組中、重度患兒意識障礙恢復時間、肌張力恢復時間均短于對照組，輕、中、重度患兒原始反射恢復時間均短于對照組，兩組比較差異具有統(tǒng)計學意義（P < 0.05）。治療后，兩組患兒血清NO、APN和IGF-1水平均升高，ET-1水平降低，同組治療前后比較差異有統(tǒng)計學意義（P < 0.05）；且治療后治療組上述指標均顯著優(yōu)于對照組，兩組比較差異有統(tǒng)計學意義（P < 0.05）。兩組NBNA評分均顯著升高，同組治療前后比較差異具有統(tǒng)計學意義（P < 0.05）；且治療后治療組NBNA評分顯著高于對照組，兩組比較差異有統(tǒng)計學意義（P < 0.05）?；卦L時，治療組患兒MDI和PDI評分均顯著高于對照組，兩組比較差異有統(tǒng)計學意義（P < 0.05）。結論 參芎葡萄糖注射液聯合腦苷肌肽治療新生兒缺氧缺血性腦病臨床效果顯著，可有效改善患兒臨床癥狀及減少后遺癥的發(fā)生，并可有效改善血清指標，具有一定的臨床推廣應用價值。

Objective To observe the clinical effect of Shenxiong Glucose Injection combined with cattle encephalon glycoside and ignotin in treatment of hypoxic ischemic encephalopathy of newborn. Methods Patients (67 cases) with hypoxic ischemic encephalopathy of newborn in Department of Neonatology in Ezhou Central Hospital from January 2015 to April 2017 were randomly divided into control (30 cases) and treatment (37 cases) groups. Patients in the control group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection, 2 mL added into normal saline 50 mL, once daily. Patients in the treatment group were iv administered with Shenxiong Glucose Injection, 50 mL/time, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, recovery of clinical signs, NO, ET-1, APN, IGF-1, NBNA, and conditions of prognosis in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 73.33% and 83.78%, respectively, and there was difference between two groups (P < 0.05). Consciousness recovery time and muscle tension recovery time of moderate and server children in the treatment group were shorter than those in the control group, with significant difference between two groups (P < 0.05). After treatment, NO, APN, and IGF-1 levels were increased, while ET-1 level was decreased, and the difference was statistically significant in the same group (P < 0.05). And those indexes in the treatment group were better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, NBNA score in two groups were increased, and the difference was statistically significant in the same group (P < 0.05). And NBNA score in the treatment group was higher than that in the control group, with significant difference between two groups (P < 0.05). When the children were followed up, MDI and PDI scores in the treatment group were higher than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Shenxiong Glucose Injection combined with cattle encephalon glycoside and ignotin has a good clinical efficacy in treatment of hypoxic ischemic encephalopathy of newborn, can significantly improve the clinical symptoms and prognosis, and can improve serum indexes, which has a certain clinical application value.

國家自然科學基金資助項目（81660794）；廣西壯族自治區(qū)衛(wèi)生和計劃生育委員會科研課題（Z2016667）