目的 探討卡馬西平片聯(lián)合注射用鼠神經(jīng)生長(zhǎng)因子治療耳鳴的臨床療效。方法 選取2014年7月—2016年7月中國(guó)人民解放軍第三七一醫(yī)院耳鼻喉科收治的耳鳴患者97例為研究對(duì)象，所有患者在隨機(jī)分組的原則下分為對(duì)照組（48例）和治療組（49例）。對(duì)照組肌肉注射注射用鼠神經(jīng)生長(zhǎng)因子，30 μg與2 mL氯化鈉注射液進(jìn)行混合，1次/d。治療組在對(duì)照組基礎(chǔ)上口服卡馬西平片，1片/次，2次/d。兩組患者均連續(xù)治療3周。觀察兩組的臨床療效，比較兩組的耳鳴致殘量表（THI）評(píng)分、耳鳴響度和耳鳴殘疾程度。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為81.25%、97.96%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組THI評(píng)分和耳鳴響度均顯著下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組無殘疾人數(shù)均顯著增多，中度殘疾人數(shù)均顯著減少，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 卡馬西平片聯(lián)合注射用鼠神經(jīng)生長(zhǎng)因子治療耳鳴具有較好的臨床療效，可降低耳鳴響度，改善耳鳴殘疾程度，安全性較好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Carbamazepine Tablets combined with Mouse Nerve Growth Factor for injection in treatment of tinnitus. Methods Patients (97 cases) with tinnitus in Department of Otolaryngology Head & Neck Surgery of the 371st Hospital of Chinese People's Liberation Army from July 2014 to July 2016 were randomly divided into the control group (48 cases) and the treatment group (48 cases). Patients in the control group were im administered with Mouse Nerve Growth Factor for injection, 30 μg mixed with normal saline 2 mL, once daily. Patients in the treatment group were po administered with Carbamazepine Tablets on the basis of the control group, 1 tablet/time, twice daily. Patients in two groups were treated for 3 weeks. After treatment, the clinical efficacies were evaluated, and THI scores, tinnitus loudness, and tinnitus disability in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.25% and 97.96%, respectively, and there was difference between two groups (P < 0.05). After treatment, THI scores and tinnitus loudness in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the numbers of no disability in two groups were significantly increased, but the number of moderate disability in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Carbamazepine Tablets combined with Mouse Nerve Growth Factor for injection has clinical curative effect in treatment of tinnitus, can decrease tinnitus loudness, and improve tinnitus disability with good safety, which has a certain clinical application value.