目的 探討采取蒲地藍(lán)消炎口服液聯(lián)合鹽酸左氧氟沙星滴耳液治療中耳炎患者的臨床療效。方法 選取監(jiān)利縣人民醫(yī)院2016年4月—2017年4月收治的急性化膿性中耳炎患者153例，隨機(jī)分成對(duì)照組（76例）和治療組（77例）。對(duì)照組患者給予鹽酸左氧氟沙星滴耳液，6滴/次，保持患耳朝上5 min，3次/d。治療組患者在對(duì)照組基礎(chǔ)上口服蒲地藍(lán)消炎口服液，10 mL/次，3次/d。兩組均連續(xù)治療14 d。觀察兩組臨床療效和復(fù)發(fā)率，比較治療前后兩組細(xì)菌清除率、炎性指標(biāo)水平和不良反應(yīng)情況。結(jié)果 治療后，對(duì)照組臨床總有效率為86.84%，明顯低于治療組的97.40%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后對(duì)照組復(fù)發(fā)率為11.84%，明顯高于治療組的2.60%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，對(duì)照組和治療組細(xì)菌清除率分別為72.37%、92.21%，兩組比較差異具有在統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者腫瘤壞死因子-α（TNF-α）、IL-8和IL-1β水平均顯著降低（P<0.05）；且治療組炎性指標(biāo)水平降低的更明顯（P<0.05）。治療期間，對(duì)照組和治療組不良反應(yīng)發(fā)生率分別為14.47%、3.90%，兩組比較差異具有在統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 蒲地藍(lán)消炎口服液聯(lián)合鹽酸左氧氟沙星滴耳液治療急性化膿性中耳炎患者臨床療效顯著，不良反應(yīng)低，具有一定的臨床推廣應(yīng)用價(jià)值。

objective To explore the clinical efficacy of Pudilan Xiaoyan Oral Liquid combined with Levofloxacin Hydrochloride Ear Drops in treatment of acute suppurative otitis media. Methods Patients (153 cases) with acute suppurative otitis media in Jianli County People's Hospital from April 2016 to April 2017 were randomly divided into control (76 cases) and treatment (77 cases) groups. Patients in the control group were given administered with Levofloxacin Hydrochloride Ear Drops, 6 drops/time, then kept the ear up for 5 min, three times daily. Patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy and recurrence rate was evaluated, and the bacterial clearance rate, the levels of inflammatory markers and adverse events in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 86.84%, which was significantly lower than 97.40% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the recurrence rate in the control group was 11.84%, which was significantly higher than 2.60% in the treatment group, with significant difference between two groups (P < 0.05). After treatment, the bacterial clearance rate in the control and treatment groups were 72.37% and 92.21%, respectively, and there were differences between two groups (P < 0.05). After treatment, the TNF-α, IL-8 and IL-1β levels in two groups were significantly decreased (P < 0.05). And these inflammatory markers levels in the treatment group decreased more significantly than those in the control group (P < 0.05). During the treatment, the incidence of adverse reactions in the control and treatment groups was 14.47% and 3.90%, respectively, with significant difference between two groups (P < 0.05). Conclusion Pudilan Xiaoyan Oral Liquid combined with Levofloxacin Hydrochloride Ear Drops has significant clinical efficacy in treatment of acute suppurative otitis media with low adverse reaction, which has a certain clinical application value.