目的 探討小兒消積止咳口服液聯(lián)合注射用炎琥寧治療兒童支原體肺炎的臨床療效。方法 選取2016年6月—2017年6月在上海市第十人民醫(yī)院治療的支原體肺炎患兒98例，隨機(jī)分為對(duì)照組和治療組，每組各49例。對(duì)照組患兒靜脈滴注注射用炎琥寧，每次5～10 mg/kg加入10%葡萄糖溶液55～250 mL，1次/d；治療組在對(duì)照組的基礎(chǔ)上口服小兒消積止咳口服液，5歲以下患兒0.2 g/次，大于5歲0.3 g/次，3次/d。兩組患兒均治療7 d。觀察兩組患兒臨床療效，比較治療前后兩組患兒臨床癥狀消失時(shí)間和住院時(shí)間以及血清細(xì)胞因子水平和C反應(yīng)蛋白（CRP）水平。結(jié)果 治療后，對(duì)照組和治療組臨床總有效率分別為77.55%、87.76%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組患兒的退熱時(shí)間、啰音消失時(shí)間、咳嗽好轉(zhuǎn)時(shí)間和平均住院時(shí)間明顯短于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組患兒血清細(xì)胞因子水平和CRP水平均明顯降低（P<0.05）；同時(shí)治療組患兒血清細(xì)胞因子水平和CRP水平均明顯低于對(duì)照組（P<0.05）。結(jié)論 小兒消積止咳口服液聯(lián)合注射用炎琥寧可明顯改善支原體肺炎患兒的臨床癥狀，縮短住院時(shí)間，具有一定的臨床推廣應(yīng)用價(jià)值。

objective To investigate the clinical efficacy of Xiaoer Xiaoji Zhike Oral Liquid combined with Potassium Sodium Pehydroandrographolide Succinate for injection in treatment of children with mycoplasma pneumonia. Methods Children (98 cases) with mycoplasma pneumonia in Shanghai Tenth People's Hospital from June 2016 to June 2017 were randomly divided into control (49 cases) and treatment (49 cases) groups. Children in the control group were iv administered with Potassium Sodium Pehydroandrographolide Succinate for injection, 5-10 mg/kg added into 10% glucose solution 55-250 mL, once daily. Children in the treatment group were po administered with Xiaoer Xiaoji Zhike Oral Liquid on the basis of the control group, 0.2 g/time for children under 5 years, and 0.3 g/time for older than 5 years, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom disappearance time, average hospitalization time, serum cytokine and CRP levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 77.55% and 87.76%, respectively, and there were differences between two groups (P < 0.05). After treatment, the antipyretic time, rale disappearance time, cough improvement time, and average hospitalization time in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the serum cytokine and CRP levels in two groups were obviously decreased (P < 0.05). And these indexes levels in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Xiaoer Xiaoji Zhike Oral Liquid combined with Potassium Sodium Pehydroandrographolide Succinate for injection in treatment of children with mycoplasma pneumonia can significantly improve clinical symptoms and shorten the hospitalization time, which has a certain clinical application value.