目的 了解2012-2016年淄博市中心醫(yī)院靜脈用藥調(diào)配中心（PIVAS）抗腫瘤藥物的不合理使用情況，為臨床合理用藥提供參考。方法 選取2012年11月-2016年12月淄博市中心醫(yī)院PIVAS記錄的不合理醫(yī)囑3 655張，對不合理用藥情況進(jìn)行回顧性分析。結(jié)果 2012年11月-2016年12月，抗腫瘤藥物的不合理醫(yī)囑共計(jì)909條，其中不合理原因主要分為溶媒選擇不合理、溶媒用量不合理、給藥劑量不合理、給藥途徑不合理和其他5種類型；以溶媒選擇不合理為主，占不合理醫(yī)囑的58.30%；注射用卡鉑和注射用奧沙利鉑的溶媒選擇不合理醫(yī)囑的構(gòu)成比分別為12.26%、10.57%；注射用吉西他濱和注射用奈達(dá)鉑的溶媒用量不合理醫(yī)囑的構(gòu)成比分別為17.26%、16.37%；艾迪注射液、鴉膽子油乳注射液和復(fù)方苦參注射液給藥劑量不合理醫(yī)囑的構(gòu)成比分別為31.25%、27.68%、24.11%。結(jié)論 淄博市中心醫(yī)院PIVAS對抗腫瘤藥物審核及干預(yù)效果顯著，有效減少不合理用藥，促進(jìn)臨床合理用藥。

Objective To investigate the unreasonable use of antitumor drugs in Pharmacy Intravenous Admixture Service (PIVAS) in Central Hospital of Zibo from 2012 to 2016, and to provide reference for rational drug use. Methods Irrational medication orders (3 655 cases) in PIVAS in Central Hospital of Zibo from November 2012 to December 2016 were checked, and the irrational medication orders were evaluated and analyzed. Results 909 Cases of antitumor drug orders were irrational from November 2012 to December 2016, which mainly included unreasonable solvent selection, inappropriate solvent dosage, improper administration dosage, irrational administration route, and others. Most was unreasonable solvent selection, accounting for 58.30%, in which the ratio of Carboplatin for injection and Oxaliplatin for injection was 12.26% and 10.57%, respectively. In terms of inappropriate solvent dosage, the ratio of Gemcitabine Hydrochloride for injection and Nedaplatin for injection was 17.26% and 16.37%, respectively. In terms of improper administration dosage, the ratio of Aidi Injection, Yadanzi Oil Emulsion Injection, and Compound Kushen Injection was 31.25%, 27.68%, and 24.11%, respectively. Conclusion The auditing and intervention on the use of antitumor drugs in PIVAS in Central Hospital of Zibo has good effect, and can reduce irrational use of drugs, and promote rational use of drugs in clinic.