目的 探討痹祺膠囊聯(lián)合玻璃酸鈉治療膝骨性關(guān)節(jié)炎的臨床療效。方法 選取2016年2月-2017年2月在渭南市中心醫(yī)院接受治療的膝骨性關(guān)節(jié)炎患者82例，依據(jù)用藥的差別分為對照組（41例）和治療組（41例）。對照組關(guān)節(jié)腔內(nèi)注射玻璃酸鈉注射液，2 mL/次，1次/周。治療組在對照組的基礎(chǔ)上口服痹祺膠囊，1.2 g/次，3次/d。兩組均經(jīng)過5周治療。觀察兩組的臨床療效，比較治療前后兩組患者WOMAC和Lysholm評分以及血清學(xué)指標(biāo)差異。結(jié)果 治療后，對照組的臨床總有效率為82.93%，顯著低于治療組患者的97.56%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者WOMAC評分明顯降低，Lysholm評分明顯升高，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組患者WOMAC和Lysholm評分比對照組改善更顯著，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者血清白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、環(huán)氧化酶-2（COX-2）、基質(zhì)金屬蛋白酶-12（MMP-12）水平均顯著降低，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組患者上述血清學(xué)指標(biāo)水平顯著低于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 痹祺膠囊聯(lián)合玻璃酸鈉治療膝骨性關(guān)節(jié)炎可有效改善患者膝關(guān)節(jié)功能，降低機體炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Biqi Capsules combined with sodium hyaluronate in treatment of knee osteoarthritis. Methods Patients (82 cases) with knee osteoarthritis in Weinan Central Hospital from February 2016 to February 2017 were divided into control (41 cases) and treatment (41 cases) groups according to the different treatments. Patients in the control group were intraarticular injection administered with Sodium Hyaluronate Injection, 2 mL/time, once weekly. Patients in the treatment group were po administered with Biqi Capsules on the basis of the control group, 1.2 g/time, three times daily. Patients in two groups were treated for 5 weeks. After treatment, the clinical efficacy was evaluated, the difference of WOMAC and Lysholm scores, and serum markers in two groups before and after treatment was compared. Results After treatment, clinical efficacy in the control group was 82.93%, which were significantly lower than 97.56% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the WOMAC score in two groups was significantly decreased, but the Lysholm score was significantly increased, and the difference was statistically significant in the same group (P<0.05). And the improvement of WOMAC and Lysholm score in the treatment group was more significant than that in the control group, with significant difference between two groups (P<0.05). After treatment, the IL-6, TNF-α, COX-2, and MMP-12 levels in two groups were significantly decreased, there were differences in the same group (P<0.05). And these serum markers levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Biqi Capsules combined with sodium hyaluronate can effectively improve the knee function and reduce the inflammatory reaction in treatment of knee osteoarthritis, which has a certain clinical application value.