目的 探討甲硝唑聯(lián)合頭孢地尼治療女性尿路感染的臨床療效。方法 選取江蘇省響水縣人民醫(yī)院于2015年11月-2016年11月收治的女性尿路感染患者221例，隨機(jī)分成對(duì)照組（110例）和治療組（111例）。對(duì)照組患者口服頭孢地尼分散片，1片/次，3次/d；治療組在對(duì)照組的基礎(chǔ)上口服甲硝唑片，1片/次，3次/d。所有患者均治療2周。評(píng)價(jià)兩組患者臨床療效，同時(shí)比較治療前后兩組患者細(xì)菌清除率和相關(guān)臨床體征消失時(shí)間。結(jié)果 對(duì)照組和治療組總有效率分別為86.36%、98.20%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組患者細(xì)菌清除率達(dá)93.75%，明顯高于對(duì)照組患者的78.79%，兩組患者細(xì)菌清除率比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組患者在腰背部疼痛、尿路疼痛以及尿頻、尿急消失時(shí)間均顯著短于對(duì)照組患者，兩者比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 頭孢地尼聯(lián)合甲硝唑治療女性尿路感染具有顯著的臨床療效，安全性好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical efficacy of metronidazole combined with cefdinir in treatment of female urinary tract infection. Methods Patients (221 cases) with urinary tract infection in Xiangshui People's Hospital from November 2015 to November 2016 were randomly divided into control (110 cases) and treatment (111 cases) groups. Patients in the control group were po administered with Cefdinir Dispersible Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Metronidazole Tablets on the basis of the control group, 1 tablet/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the bacterial clearance rate and the disappearance time of clinical signs in two groups before and after treatment were compared. Result After treatment, the clinical efficacy in the control and treatment groups were 86.36% and 98.20%, respectively, and there were differences between two groups (P<0.05). After treatment, the bacterial clearance rate in the treatment group was 93.75%, which was significantly higher than 78.79% in the control groups, and there were differences between two groups (P<0.05). After treatment, the disappearance time of lumbar back pain, urinary tract pain and urinary frequency, urgency in the treatment group significantly lower than that in the control group, and there were differences between two groups (P<0.05). Conclusion Metronidazole combined with cefdinir has significant clinical efficacy in treatment of female urinary tract infection with good safety, which has a certain clinical application value.