目的 探討胃復(fù)春片聯(lián)合枸櫞酸莫沙必利片治療慢性萎縮性胃炎的臨床療效。方法 選取2015年7月-2017年7月在上海市浦東新區(qū)人民醫(yī)院進(jìn)行治療的慢性萎縮性胃炎患者212例為研究對象，入選者根據(jù)用藥的差別分為對照組和治療組，每組各106例。對照組口服枸櫞酸莫沙必利片，5 mg/次，3次/d。治療組在對照組治療基礎(chǔ)上口服胃復(fù)春片，4片/次，3次/d。兩組均連續(xù)治療2周。觀察兩組的臨床療效，比較兩組的臨床癥狀評分和血清學(xué)指標(biāo)。結(jié)果 治療后，對照組和治療組的總有效率分別為83.96%、98.11%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組胃脘疼痛、胃中嘈雜、噯氣泛酸和口苦口干評分均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清白細(xì)胞介素-1β（IL-1β）、人可溶性白介素-2受體（sIL-2R）、胃泌素（GAS）、胃動(dòng)素（MTL）水平明顯降低，胃泌素-17（G-17）水平明顯增高（P<0.05），同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 胃復(fù)春片聯(lián)合枸櫞酸莫沙必利片治療慢性萎縮性胃炎具有較好的臨床療效，可改善臨床癥狀，降低機(jī)體炎癥反應(yīng)，調(diào)節(jié)胃腸激素水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Weifuchun Tablets combined with Mosapride Citrate Tablets in treatment of chronic atrophic gastritis. Methods Patients (212 cases) with c chronic atrophic gastritis in Shanghai Pudong New Area People's Hospital from July 2015 to July 2017 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 106 cases. Patients in the control group were po administered with Mosapride Citrate Tablets, 5 mg/time, three times daily. Patients in the treatment group were po administered with Weifuchun Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom scores and serological indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.96% and 98.11%, respectively, and there was difference between two groups (P<0.05). After treatment, the scores of epigastric pain, noisy stomach, eructation pantothenic acid, bitter taste, and dry throat in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of serum IL-1β, sIL-2R, GAS, and MTL in two groups were significantly decreased, but the levels of G-17 in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Weifuchun Tablets combined with Mosapride Citrate Tablets has clinical curative effect in treatment of chronic atrophic gastritis, can improve clinical symptoms, decrease the inflammatory reaction, and regulate the level of gastrointestinal hormones, which has a certain clinical application value.