目的 探討注射用鹽酸頭孢吡肟聯(lián)合注射用替加環(huán)素治療克雷伯菌肺炎的臨床療效。方法 回顧分析2015年2月-2016年2月在河南省人民醫(yī)院進(jìn)行治療的109例克雷伯菌肺炎患者，所有患者分為對(duì)照組（54例）和治療組（55例）。對(duì)照組靜脈滴注注射用替加環(huán)素，首次劑量100 mg，然后調(diào)整為50 mg/次，1次/12 h。治療組在對(duì)照組的基礎(chǔ)上靜脈注射注射用鹽酸頭孢吡肟，2 g/次，1次/12 h。所有患者均連續(xù)治療1周。觀察兩組的臨床療效，比較兩組的病原菌清除率、體溫以及實(shí)驗(yàn)室指標(biāo)。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為81.48%、96.36%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，對(duì)照組和治療組的病原菌清除率分別為83.33%、98.18%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組體溫、C-反應(yīng)蛋白和降鈣素原均顯著降低，而中性粒細(xì)胞百分比均顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 注射用鹽酸頭孢吡肟聯(lián)合注射用替加環(huán)素治療克雷伯菌肺炎具有較好的臨床療效，可降低C-反應(yīng)蛋白和降鈣素原水平，升高中性粒細(xì)胞百分比，安全性較好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Cefepime Hydrochloride for injection combined with Tigecycline for injection in treatment of klebsiella pneumonia. Methods Patients (109 cases) with klebsiella pneumonia in Henan Province People's Hospital from February 2015 to February 2016 were randomly divided into the control group (54 cases) and treatment group (55 cases). Patients in the control group were iv administered with Tigecycline for injection, first dose 100 mg, then adjust to 50 mg/time, once every 12 hours. Patients in the treatment group were iv administered with Cefepime Hydrochloride for injection on the basis of the control group, 2 g/time, once every 12 hours. Patients in two groups were treated for 1 week. After treatment, the clinical efficacies were evaluated, and clearance rate of pathogens, body temperature and laboratory indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.48% and 96.36%, and the clearance rates of pathogens in the control and treatment groups were 83.33% and 98.18%, respectively, and there was difference between two groups (P<0.05). After treatment, body temperature, C-reactive protein, and procalcitonin in two groups were significantly decreased, but the percentage of neutrophils in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Cefepime Hydrochloride for injection combined with Tigecycline for injection has curative effect in treatment of klebsiella pneumonia, can decrease C-reactive protein and procalcitonin levels, and increase the percentage of neutrophils, with good safety, which has a certain clinical application value.